4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- CAS No.
- 55224-94-7
- Chemical Name:
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- Synonyms
- AP-18;AP-18, TRPA1 receptor antagonist;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal
- CBNumber:
- CB42096355
- Molecular Formula:
- C11H12ClNO
- Molecular Weight:
- 209.67
- MDL Number:
- MFCD00102250
- MOL File:
- 55224-94-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7232 | AP-18 ≥98% (HPLC), solid | 55224-94-7 | 5mg | $138 | 2024-03-01 | Buy |
| Sigma-Aldrich | A7232 | AP-18 ≥98% (HPLC), solid | 55224-94-7 | 25mg | $262.2 | 2024-03-01 | Buy |
| Cayman Chemical | 11912 | AP-18 ≥98% | 55224-94-7 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 11912 | AP-18 ≥98% | 55224-94-7 | 10mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 11912 | AP-18 ≥98% | 55224-94-7 | 25mg | $193 | 2024-03-01 | Buy |
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties,Uses,Production
Description
AP-
Uses
AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice
Uses
AP-18 is a channel blocker that inhibits TRPA1.
Biological Activity
Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Biochem/physiol Actions
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.
in vivo
ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception.
storage
+4°C
References
References”Citations:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57423 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
