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DIHYDROERGOTAMINE MESYLATE

DIHYDROERGOTAMINE MESYLATE structure

CAS No.: 6190-39-2

Chemical Name:: DIHYDROERGOTAMINE MESYLATE

Synonyms: Agit;detms;dhe45;DET MS;MT 300;DHE-45;Diergo;Ergont;Ikaran;Morena

CBNumber:: CB4221630

Molecular Formula:: C33H37N5O5.CH4O3S

Molecular Weight:: 679.79

MDL Number:: MFCD05618219

MOL File:: 6190-39-2.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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DIHYDROERGOTAMINE MESYLATE Properties

Melting point	232°C
refractive index	-20 ° (C=0.25, JP Method)
storage temp.	Store at RT
solubility	methanol: 21 mg/mL
form	powder
color	white
Merck	14,3174
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference	6190-39-2(CAS DataBase Reference)
FDA UNII	81AXN7R2QT
Proposition 65 List	Dihydroergotamine Mesylate

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H312+H332

Precautionary statements

P261-P271-P280-P302+P352+P312-P304+P340+P312-P362+P364

Hazard Codes

Risk Statements

20/21/22

Safety Statements

RIDADR

1544

WGK Germany

RTECS

KE7920000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2939690000

NFPA 704

	0
3		0

DIHYDROERGOTAMINE MESYLATE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D1950000	Dihydroergotamine mesilate European Pharmacopoeia (EP) Reference Standard	6190-39-2	d1950000	$153	2024-03-01	Buy
TCI Chemical	D2633	Dihydroergotamine Mesylate >97.0%(HPLC)	6190-39-2	100mg	$85	2024-03-01	Buy
TCI Chemical	D2633	Dihydroergotamine Mesylate >97.0%(HPLC)	6190-39-2	1g	$311	2024-03-01	Buy
Alfa Aesar	J63840	Dihydroergotamine methanesulfonate	6190-39-2	1g	$444.65	2024-03-01	Buy
Alfa Aesar	J63840	Dihydroergotamine methanesulfonate	6190-39-2	100mg	$88.3	2023-06-20	Buy

Product number	Packaging	Price	Buy
D1950000	d1950000	$153	Buy
D2633	100mg	$85	Buy
D2633	1g	$311	Buy
J63840	1g	$444.65	Buy
J63840	100mg	$88.3	Buy

DIHYDROERGOTAMINE MESYLATE Chemical Properties,Uses,Production

Description

Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4

Chemical Properties

White to Off-White Solid

Uses

α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.

Uses

Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors

Uses

vasoconstrictor, antimigraine

Definition

ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.

brand name

D.H.E. 45 (Valeant); Migranal (Valeant) .

Biological Activity

Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.

storage

Room temperature

References

Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655 Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15 Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144 Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33

DIHYDROERGOTAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

6-methylergoline-8beta-carboxylic acid

DIHYDROERGOTAMINE MESYLATE Suppliers

Global( 149)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Aston Chemical	13000000000	sales@astonchem.com	United States	1634	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9725	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5983	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Aston Chemical	58
changzhou huayang technology co., ltd	58
InvivoChem	58
Henan Allgreen Chemical Co.,LTD	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from DIHYDROERGOTAMINE MESYLATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-08	DIHYDROERGOTAMINE MESYLATE 6190-39-2	US $1.00-2.00 / KG	1KG	98%	1kg,10kg,100kg	Career Henan Chemical Co

DIHYDROERGOTAMINE MESYLATE
6190-39-2
US $1.00-2.00 / KG
98%
Career Henan Chemical Co

DIHYDROERGOTAMINE MESYLATE Spectrum

DIHYDROERGOTAMINE MESYLATE(6190-39-2)MS DIHYDROERGOTAMINE MESYLATE(6190-39-2)¹HNMR DIHYDROERGOTAMINE MESYLATE(6190-39-2)¹³CNMR DIHYDROERGOTAMINE MESYLATE(6190-39-2)IR1 DIHYDROERGOTAMINE MESYLATE(6190-39-2)IR2

6190-39-2(DIHYDROERGOTAMINE MESYLATE)Related Search:

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DIHYDROERGOTAMINE ergotamine DIHYDROERGOTAMINE MESYLATE Dihydroergotamine Mesylate USP,BP,JP,Eur,Ph

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5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trionemonomethanesulfonate 9,10-dihydroergotaminemesylate 9,10-dihydro-ergotaminmonomethanesulfonate(salt) Agit Angionorm D.H.E. 45 Dergotamine DET MS detms Dihydroergotamine Mesylate (250 mg) (List Chemical) MT 300 Dihydroergotamine Mesylate (250 mg) Dihydroergotamine Mesylate (500 mg) (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-Methyl-5'-(phenylMethyl)ergotaMan-3',6',18-trione dhe45 DHE-45 Diergo Dihydergot Dihydroergotamine monomethanesulfonate dihydroergotaminemesilate Dirgotarl Endophleban Ergomimet Ergont Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt) Ergotonin Ikaran Migranal Morena Orstanorm Tonopres Verladyn 9,10-DIHYDRO-12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)ERGOTAMAN-3',6',18-TRIONE MESYLATE DIHYDROERGOTAMINE MESYLATE DIHYDROERGOTAMINE METHANESULFONATE DIHYDROERGOTAMINE METHANESULFONATE SALT Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt) DIHYDROERGOTAMINEMESYLATE,USP ZOZUFVUTVAZUDP-OESQIVJBSA-N Dihydroergocristine Mesilate Impurity 5（Dihydroergocristine Mesilate EP Impurity E） Dihydroergotamine for peak identification CRS Dihydroergotamine mesilate CRS (6aR,9R,10aR)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate DIHYDROERGOTAMINE MESYLATE USP/EP/BP Dihydroergotamine Mesylate (1.0mg/ml in DMSO) Dihydroergotamine for peak identification (Y0000831) Dihydroergotamine mesilate (D1950000) Dihydroergotamine Mesylate (1202005) Dihydroergotamine Mesylate (DHE Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5',10)-, monomethanesulfonate (salt) Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1) 6190-39-2 C34H41N5O8S C33H37N5O5CH3SO3H C33H37N5O5CH4O3S MIGRANAL