2,4'-Dibromoacetophenone
- CAS No.
- 99-73-0
- Chemical Name:
- 2,4'-Dibromoacetophenone
- Synonyms
- 99-73-0;2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE;PBPB;2-BROMO-1-(4-BROMOPHENYL)ETHANONE;P-BROMOPHENACYL BROMIDE;4-BROMOPHENACYL BROMIDE;p-bromophenacyl-8;AKOS BBS-00000865;GSK-3β Inhibitor VII;BromophenacylBromide
- CBNumber:
- CB4239093
- Molecular Formula:
- C8H6Br2O
- Molecular Weight:
- 277.94
- MDL Number:
- MFCD00000200
- MOL File:
- 99-73-0.mol
- MSDS File:
- SDS
Melting point | 108-110 °C(lit.) |
---|---|
Boiling point | 1415°C/760mm |
Density | 1.7855 (rough estimate) |
refractive index | 1.5560 (estimate) |
storage temp. | Store below +30°C. |
solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol |
form | Crystalline Solid |
color | Slightly yellow to beige |
Water Solubility | Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water. |
Sensitive | Lachrymatory |
Merck | 14,1427 |
BRN | 607604 |
Stability | Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents. |
InChIKey | FKJSFKCZZIXQIP-UHFFFAOYSA-N |
CAS DataBase Reference | 99-73-0(CAS DataBase Reference) |
FDA UNII | PN0FRW1G4Z |
EPA Substance Registry System | Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
Hazard Codes | C | |||||||||
Risk Statements | 34 | |||||||||
Safety Statements | 26-36/37/39-45 | |||||||||
RIDADR | UN 3261 8/PG 2 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | AM6950000 | |||||||||
F | 19-21 | |||||||||
Hazard Note | Corrosive/Lachrymatory | |||||||||
TSCA | T | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29147090 | |||||||||
NFPA 704 |
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2,4'-Dibromoacetophenone price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 68082 | 2,4′-Dibromoacetophenone for HPLC derivatization, ≥99.0% (HPLC) | 99-73-0 | 5g | $78.3 | 2024-03-01 | Buy |
Sigma-Aldrich | 361548 | GSK-3β Inhibitor VII | 99-73-0 | 5mg | $172 | 2024-03-01 | Buy |
TCI Chemical | A5501 | 4-Bromophenacyl Bromide [for HPLC Labeling] >99.0%(T) | 99-73-0 | 5g | $115 | 2024-03-01 | Buy |
TCI Chemical | D0164 | 4-Bromophenacyl Bromide >98.0%(GC) | 99-73-0 | 25g | $35 | 2024-03-01 | Buy |
Alfa Aesar | A13687 | 2,4'-Dibromoacetophenone, 98+% | 99-73-0 | 25g | $62.65 | 2024-03-01 | Buy |
2,4'-Dibromoacetophenone Chemical Properties,Uses,Production
Chemical Properties
2,4'-Dibromoacetophenone is off-white crystals or powder
Uses
Identification of carboxylic acids.
Uses
Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3
Uses
2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.
General Description
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]
2,4'-Dibromoacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12459 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16220 | 58 |
Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29901 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2141 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from 2,4'-Dibromoacetophenone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-15 | 2,4′-dibromoacetophenone 2
99-73-0
|
US $1.00-100.00 / mg | 100mg | 0.99 | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | ||
2024-04-12 | 2,4'-Dibromoacetophenone
99-73-0
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
2023-08-31 | 2,4'-Dibromoacetophenone
99-73-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- 2,4′-dibromoacetophenone 2
99-73-0
- US $1.00-100.00 / mg
- 0.99
- ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
- 2,4'-Dibromoacetophenone
99-73-0
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
- 2,4'-Dibromoacetophenone
99-73-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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