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(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one structure

CAS No.: 126860-83-1

Chemical Name:: (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

Synonyms: MC-1046;24-carbonyl-Calcipotriol;IMpurity A of Calcipotriol;Calcipotriol EP Impurity A: Ketone analog;Calcipotriol Impurity 1(Calcipotriol EP Impurity A);(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%)

CBNumber:: CB42414777

Molecular Formula:: C27H38O3

Molecular Weight:: 410.59

MDL Number:: MFCD00872035

MOL File:: 126860-83-1.mol

Last updated:2024-07-02 08:55:08

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(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Properties

Boiling point	584.2±50.0 °C(Predicted)
Density	1.12±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility	Soluble in DMSO
form	Powder
pka	14.43±0.40(Predicted)
color	Light yellow to yellow
FDA UNII	G70BS4HF9Z

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C988310	(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)	126860-83-1	0.25mg	$305	2021-12-16	Buy
ChemScene	CS-1162	MC1046	126860-83-1	1mg	$500	2021-12-16	Buy
Medical Isotopes, Inc.	68944	(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)	126860-83-1	0.25mg	$750	2021-12-16	Buy
ApexBio Technology	A3588	MC1046	126860-83-1	1mg	$1339	2021-12-16	Buy

Product number	Packaging	Price	Buy
C988310	0.25mg	$305	Buy
CS-1162	1mg	$500	Buy
68944	0.25mg	$750	Buy
A3588	1mg	$1339	Buy

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Chemical Properties,Uses,Production

Uses

MC 1046 is a vitamin D3 analogue with similar effects. Impurity of Calcipotriol (C144200), an antipsoriatic.

Biological Activity

mc 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and dna-synthesis of cells possessing the receptor for 1,25(oh)2d3. mc 1046 is the metabolite of calcipotrioi (mc 903), which is a novel analogue of the physiologically active metabolite of vitamin d3.

in vitro

the biological effects on the u937 cells of the two major metabolites of mc 903 (mc 1046 and mc 1080) were investigated. results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound [1].

in vivo

mc 903 is a novel analogue of the physiologically active metabolite of 1,25(oh)2d3. unlike the similar effects on cell proliferation and cell differentiation in vitro, mc 903 has 100-200 times less effect on calcium metabolism in vivo. moreover, rat study indicats that the effect of mc 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes mc 903 suitable for topical treatment of psoriasis [1].

References

[1] kissmeyer am, binderup l. calcipotriol (mc 903): pharmacokinetics in rats and biological activities of metabolites. a comparative study with 1,25(oh)2d3. biochem pharmacol. 1991;41(11):1601-6.

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Preparation Products And Raw materials

Raw materials

Preparation Products

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Suppliers

Global( 78)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5978	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
QUALITY CONTROL SOLUTIONS LTD.	0755-66853366; 13670046396	ORDERS@QCSRM.COM	China	24326	58
Hefei fuya biotechnology co. LTD	18096409024	sales02@foreversyn.com	China	1917	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Standardpharm Co. Ltd.	58
BOC Sciences	58
career henan chemical co	58
Wuhan Fortuna Chemical Co., Ltd	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Aladdin Scientific	58
QUALITY CONTROL SOLUTIONS LTD.	58
Hefei fuya biotechnology co. LTD	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-27	MC 1046 126860-83-1	US $0.00 / KG	1KG	98%min	30tons	WUHAN FORTUNA CHEMICAL CO., LTD
	2020-03-06	(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one 126860-83-1	US $1.00 / KG	1KG	97%-99.9%	200kg	Career Henan Chemical Co

MC 1046
126860-83-1
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
126860-83-1
US $1.00 / KG
97%-99.9%
Career Henan Chemical Co

126860-83-1((5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one)Related Search:

(5E)-Calcipotriene Calcipotriene 24R-Calcipotriol (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one MC-1046 IMpurity A of Calcipotriol (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%) (1alpha,3beta,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-secochola-5,7,10(19),22-tetraen-24-one Calcipotriol EP Impurity A: Ketone analog Calcipotriol Impurity 1(Calcipotriol EP Impurity A) Calcipotriol EP Impurity A/(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one 2-Penten-1-one, 1-cyclopropyl-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-, (2E,4R)- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one (5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one 24-carbonyl-Calcipotriol Calcipotriol EP Impurity A/(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one 126860-83-1 Matabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals