Artemether
- CAS No.
- 71963-77-4
- Chemical Name:
- Artemether
- Synonyms
- artMether;Artimether;ARTHEMETER;ArteMether (SM-224);SM-224;Gvither;ArteMos;ArtenaM;Falcidol;Artesian
- CBNumber:
- CB4248286
- Molecular Formula:
- C16H26O5
- Molecular Weight:
- 298.37
- MDL Number:
- MFCD00866205
- MOL File:
- 71963-77-4.mol
- MSDS File:
- SDS
| Melting point | 86-88°C |
|---|---|
| alpha | D19.5 +171° (c = 2.59 in CHCl3) |
| Boiling point | 359.79°C (rough estimate) |
| Density | 1.0733 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light brown |
| optical activity | [α]/D +155 to +175°, c = 0.5 in methanol |
| Merck | 14,815 |
| InChI | InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 |
| InChIKey | SXYIRMFQILZOAM-HVNFFKDJSA-N |
| SMILES | O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1 |
| FDA UNII | C7D6T3H22J |
| ATC code | P01BE02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H242-H302 | |||||||||
| Precautionary statements | P210-P235-P280-P301+P312-P370+P378-P410 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KD4165000 | |||||||||
| HS Code | 29329930 | |||||||||
| Hazardous Substances Data | 71963-77-4(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) | |||||||||
| NFPA 704 |
|
Artemether price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9361 | Artemether ≥98% (HPLC) | 71963-77-4 | 5mg | $90.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR3423 | Artemether certified reference material, pharmaceutical secondary standard | 71963-77-4 | 200MG | $222 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1042780 | Artemether United States Pharmacopeia (USP) Reference Standard | 71963-77-4 | 100mg | $261.6 | 2024-03-01 | Buy |
| TCI Chemical | A2190 | Artemether >98.0%(HPLC) | 71963-77-4 | 5g | $80 | 2024-03-01 | Buy |
| TCI Chemical | A2190 | Artemether >98.0%(HPLC) | 71963-77-4 | 25g | $237 | 2024-03-01 | Buy |
Artemether Chemical Properties,Uses,Production
Description
Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemical Properties
White Solid
Uses
Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
Uses
atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist
Uses
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Definition
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.
General Description
Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.
Biochem/physiol Actions
Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Safety Profile
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.
target
Antifection
storage
Store at -20°C
Artemether Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2994 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
View Lastest Price from Artemether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-02 | Artemether
71963-77-4
|
US $415.00 / Kg/Bag | 1KG | 99% | 5T | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2025-01-02 | Artemether
71963-77-4
|
US $1000.00-400.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-12-27 | Artemether
71963-77-4
|
US $0.00 / Kg/Bag | 1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Artemether
71963-77-4
- US $415.00 / Kg/Bag
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- Artemether
71963-77-4
- US $1000.00-400.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Artemether
71963-77-4
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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