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ChemicalBook >> CAS DataBase List >>(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Structure
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide structure
CAS No.
910634-41-2
Chemical Name:
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
Synonyms
KF 89617;LY 2523355;Litronesib;LY-2523355; KF-89617;Litronesib (LY2523355);(R)-N-(5-(((2-(Ethylamino)ethyl)sulfonamido)methyl)-5-phenyl-4-pivaloyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)pivalamide;(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide;Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (5R)-
CBNumber:
CB42484743
Molecular Formula:
C23H37N5O4S2
Molecular Weight:
511.7
MDL Number:
MOL File:
910634-41-2.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Properties

Density 1.23±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 50 mg/mL (97.71 mM)
form Solid
pka 9.47±0.40(Predicted)
color White to off-white
FDA UNII 6611F8KYCV
NCI Drug Dictionary litronesib

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FD151502 (-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide 910634-41-2 2mg $59 2021-12-16 Buy
Biosynth Carbosynth FD151502 (-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide 910634-41-2 5mg $117 2021-12-16 Buy
ChemScene CS-5194 Litronesib 99.59% 910634-41-2 5mg $132 2021-12-16 Buy
Biosynth Carbosynth FD151502 (-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide 910634-41-2 10mg $203 2021-12-16 Buy
ChemScene CS-5194 Litronesib 99.59% 910634-41-2 10mg $228 2021-12-16 Buy
Product number Packaging Price Buy
FD151502 2mg $59 Buy
FD151502 5mg $117 Buy
CS-5194 5mg $132 Buy
FD151502 10mg $203 Buy
CS-5194 10mg $228 Buy

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Chemical Properties,Uses,Production

Uses

Litronesib is a selective allosteric kinesin Eg5 inhibitor in patients with advanced cancer.

in vivo

Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].

IC 50

Eg5

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 6000 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58

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Litronesib pictures 2024-10-28 Litronesib
910634-41-2
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
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    910634-41-2
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910634-41-2((-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide)Related Search:

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(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide KF 89617 Litronesib LY 2523355 Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (5R)- LY-2523355; KF-89617 (R)-N-(5-(((2-(Ethylamino)ethyl)sulfonamido)methyl)-5-phenyl-4-pivaloyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)pivalamide Litronesib (LY2523355) 910634-41-2 C23H37N5O4S2