ChemicalBook >> CAS DataBase List >>1H-1-Ethyl Candesartan Cilexetil
1H-1-Ethyl Candesartan Cilexetil
- CAS No.
- 914613-35-7
- Chemical Name:
- 1H-1-Ethyl Candesartan Cilexetil
- Synonyms
- Candesartan EP Imp E;Candesartan Impurity 2;Candesartan EP Impurity-E;1H-1-Ethyl Candesartan Cilexetil;Candesartan Cilexetil impurity E;Candesartan Cilexetil EP IMpurity E;Candesartan Cilexetil Impurity 5(EP Impurity E);Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E);2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
- CBNumber:
- CB42508599
- Molecular Formula:
- C35H38N6O6
- Molecular Weight:
- 638.71282
- MDL Number:
- MFCD18382323
- MOL File:
- 914613-35-7.mol
- MSDS File:
- SDS
Last updated:2024-11-19 23:02:33
| Melting point | 90-93°C |
|---|---|
| Boiling point | 842.0±75.0 °C(Predicted) |
| Density | 1.32 |
| storage temp. | Refrigerator |
| solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 3.95±0.10(Predicted) |
| FDA UNII | IN72J7R432 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
1H-1-Ethyl Candesartan Cilexetil price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17912 | 1H-1-ethyl Candesartan Cilexetil ≥98% | 914613-35-7 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 17912 | 1H-1-ethyl Candesartan Cilexetil ≥98% | 914613-35-7 | 5mg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 17912 | 1H-1-ethyl Candesartan Cilexetil ≥98% | 914613-35-7 | 10mg | $330 | 2024-03-01 | Buy |
| TRC | E900870 | 1H-1-EthylCandesartanCilexetil | 914613-35-7 | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | C5023 | 1H-1-ethylCandesartanCilexetil | 914613-35-7 | 10mg | $374 | 2021-12-16 | Buy |
1H-1-Ethyl Candesartan Cilexetil Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Candesartan Cilexetil Impurity E (PHARMEUROPA).
Biological Activity
1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].
References
[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.
1H-1-Ethyl Candesartan Cilexetil Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 77)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3389 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24326 | 58 |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3633 | 55 |
| Hunan Zengda Biological Technology Co., LTD | 18711085600 | 1652923704@qq.com | China | 4582 | 58 |
View Lastest Price from 1H-1-Ethyl Candesartan Cilexetil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 1H-1-ethyl Candesartan Cilexetil
914613-35-7
|
US $35.00-136.00 / mg | 97.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-09-20 | Candesartan Cilexetil EP Impurity E
914613-35-7
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 1H-1-ethyl Candesartan Cilexetil
914613-35-7
- US $35.00-136.00 / mg
- 97.95%
- TargetMol Chemicals Inc.
-
- Candesartan Cilexetil EP Impurity E
914613-35-7
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
914613-35-7(1H-1-Ethyl Candesartan Cilexetil)Related Search:
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O-Desethyl Candesartan Cilexetil
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Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
N-Trityl Candesartan Ethyl Ester
Trityl candesartan cilexetil
Candesartan Cilexetil Methoxy Analogue
1of4
1H-1-Ethyl Candesartan Cilexetil
2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
Candesartan Cilexetil EP IMpurity E
Candesartan Cilexetil EP Impurity EQ: What is
Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of
Candesartan Cilexetil EP Impurity E Q: What is the storage condition of
Candesartan Cilexetil EP Impurity E Q: What are the applications of
Candesartan Cilexetil EP Impurity E
Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Candesartan EP Imp E
Candesartan Cilexetil Impurity 5(EP Impurity E)
Candesartan Impurity 2
Candesartan Cilexetil impurity E
Candesartan Cilexetil,1H1ethyl Candesartan Cilexetil,Inhibitor,1H 1 ethyl Candesartan Cilexetil,inhibit
Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E)
(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1- ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylate
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (1-ethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-carboxylate
Candesartan EP Impurity-E
914613-35-7
Aromatics
Heterocycles
Impurities
Intermediates & Fine Chemicals
Pharmaceuticals