ChemicalBook >> CAS DataBase List >>(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
- CAS No.
- 300353-13-3
- Chemical Name:
- (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
- Synonyms
- Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
- CBNumber:
- CB42516200
- Molecular Formula:
- C18H22N2O3S2
- Molecular Weight:
- 378.51
- MDL Number:
- MOL File:
- 300353-13-3.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:08
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Axon Medchem | Axon1356 | RO28-1675-RO28-0450,(R)- 99% | 300353-13-3 | 2mg | $115.5 | 2021-12-16 | Buy |
Axon Medchem | Axon1356 | RO28-1675-RO28-0450,(R)- 99% | 300353-13-3 | 5mg | $159.5 | 2021-12-16 | Buy |
ChemScene | CS-2016 | RO-28-1675 99.95% | 300353-13-3 | 5mg | $258 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0004737 | (R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE 95.00% | 300353-13-3 | 2MG | $262 | 2021-12-16 | Buy |
ChemScene | CS-2016 | RO-28-1675 99.95% | 300353-13-3 | 10mg | $444 | 2021-12-16 | Buy |
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Uses,Production
Definition
ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.
Biological Activity
RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.
in vitro
RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).
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in vivo
RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.
Animal Model: | 10 weeks old male C57BL/6J mice |
Dosage: | 50 mg/kg |
Administration: | Oral administration |
Result: | Reduced blood glucose levels. |
Animal Model: | C57BL/6J mice |
Dosage: td> | 10 mg/kg |
Administration: | Oral administr ation |
Result: | AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered. |
target
EC50: 54 nM (glucokinase)
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials
Raw materials
Preparation Products
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers
Global( 44)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
Ro 0281675
BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
Ro 28-1675
RO 028-1675;RO 0281675
RO 28-1675 - RO 28-0450, (R)-
RO281675,RO 28 1675
RO 28-1675 (Ro 0281675)
300353-13-3