Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
- CAS No.
- 69819-86-9
- Chemical Name:
- Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
- Synonyms
- Darinaparsin;SP02);ZIO 101;EOS-60608;Selurampanel;Darinaparsin (ZIO101;Dimethylarsinic glutathione;Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
- CBNumber:
- CB42563431
- Molecular Formula:
- C12H22AsN3O6S
- Molecular Weight:
- 411.3
- MDL Number:
- MFCD17215931
- MOL File:
- 69819-86-9.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:10.0(Max Conc. mg/mL);24.31(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2.21±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 9XX54M675G |
| NCI Drug Dictionary | darinaparsin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21659 | Darinaparsin ≥95% | 69819-86-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21659 | Darinaparsin ≥95% | 69819-86-9 | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 21659 | Darinaparsin ≥95% | 69819-86-9 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 21659 | Darinaparsin ≥95% | 69819-86-9 | 25mg | $420 | 2024-03-01 | Buy |
| TRC | D193425 | Darinaparsin | 69819-86-9 | 250mg | $765 | 2021-12-16 | Buy |
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Chemical Properties,Uses,Production
Description
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 μM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 μM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 μM, respectively). It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 μM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.
Uses
Darinaparsin-d5 is the isotope labelled analog of Darinaparsin. Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.?? Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.
Definition
ChEBI: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-(dimethylarsinothio)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid is a peptide.
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Alabiochem Tech.Co., Ltd. | 0512-58900862 400-0707518 | sales@alabiochem.com | China | 995 | 59 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |