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3,5-dimethyl PIT-1

3,5-dimethyl PIT-1 Structure
3,5-dimethyl PIT-1 structure
CAS No.
701947-53-7
Chemical Name:
3,5-dimethyl PIT-1
Synonyms
DM-PIT-1;3,5-dimethyl PIT-1;DM-PIT-1 (3,5-dimethyl PIT-1);3,5 dimethyl PIT 1,3,5dimethyl PIT1;PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem;N-[(2-hydroxy-5-nitrophenyl)carbamothioyl]-3,5-dimethylbenzamide;Benzamide, N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-
CBNumber:
CB42590015
Molecular Formula:
C16H15N3O4S
Molecular Weight:
345.37
MDL Number:
MOL File:
701947-53-7.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:17
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3,5-dimethyl PIT-1 Properties

storage temp. +2C to +8C
solubility DMF:30.0(Max Conc. mg/mL);86.86(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);57.91(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM)
form Off-white powder

3,5-dimethyl PIT-1 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 524619 PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem
The PIP3 Antagonist II, DM-PIT-1, also referenced under CAS 701947-53-7, controls the biological activity of PIP3. 		701947-53-7 25mg $251 2024-03-01 Buy
Cayman Chemical 10727 3,5-dimethyl PIT-1 ≥98% 701947-53-7 1mg $26 2024-03-01 Buy
Cayman Chemical 10727 3,5-dimethyl PIT-1 ≥98% 701947-53-7 5mg $111 2024-03-01 Buy
Cayman Chemical 10727 3,5-dimethyl PIT-1 ≥98% 701947-53-7 10mg $195 2024-03-01 Buy
Cayman Chemical 10727 3,5-dimethyl PIT-1 ≥98% 701947-53-7 25mg $426 2024-03-01 Buy
Product number Packaging Price Buy
524619 25mg $251 Buy
10727 1mg $26 Buy
10727 5mg $111 Buy
10727 10mg $195 Buy
10727 25mg $426 Buy

3,5-dimethyl PIT-1 Chemical Properties,Uses,Production

Description

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM). 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.

General Description

A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 (Cat. No. 524615) for binding PH domains of Akt1 (IC50 ≥31 μM), ARNO, GRP1, and PKD1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100 μM for 3 d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1 h 100 μM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-δ and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1 mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1 mg/kg micelles-formulated or 0.4 mg/kg free drug daily i.v., respectively).

3,5-dimethyl PIT-1 Preparation Products And Raw materials

Raw materials

Preparation Products

3,5-dimethyl PIT-1 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7979 58
Supplier Advantage
Aladdin Scientific 		58
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
3,5-dimethyl PIT-1 N-[(2-hydroxy-5-nitrophenyl)carbamothioyl]-3,5-dimethylbenzamide DM-PIT-1 (3,5-dimethyl PIT-1) PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem Benzamide, N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl- DM-PIT-1 3,5 dimethyl PIT 1,3,5dimethyl PIT1 701947-53-7