Eicosapentaenoyl Ethanolamide
- CAS No.
- 109001-03-8
- Chemical Name:
- Eicosapentaenoyl Ethanolamide
- Synonyms
- EPEA;Eicosapentaenoyl Ethanolamide;5(Z),8(Z),11(Z),14(Z),17(Z)-Eicosapentaenoyl Ethanolamide;N-(2-hydroxyethyl)-5(Z),8(Z),11(Z),14(Z),17(Z)-eicosapentaenamide;(5Z,8Z,11Z,14Z,17Z)-N-(2-hydroxyethyl)icosa-5,8,11,14,17-pentaenamide;(5Z,8Z,11Z,14Z,17Z)-N-(2-Hydroxyethyl)-5,8,11,14,17-eicosapentaenamide;5,8,11,14,17-Eicosapentaenamide, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z,17Z)-
- CBNumber:
- CB42590909
- Molecular Formula:
- C22H35NO2
- Molecular Weight:
- 345.52
- MDL Number:
- MFCD22416528
- MOL File:
- 109001-03-8.mol
| Boiling point | 522.5±50.0 °C(Predicted) |
|---|---|
| Density | 0.951±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml |
| pka | 14.48±0.10(Predicted) |
| form | oil |
| color | colorless to yellow |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Eicosapentaenoyl Ethanolamide price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0384 | Eicosapentaenoyl ethanolamide 5mg/mL in absolute ethanol, ≥98% (HPLC) | 109001-03-8 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 10964 | Eicosapentaenoyl Ethanolamide ≥98% | 109001-03-8 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 10964 | Eicosapentaenoyl Ethanolamide ≥98% | 109001-03-8 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 10964 | Eicosapentaenoyl Ethanolamide ≥98% | 109001-03-8 | 50mg | $477 | 2024-03-01 | Buy |
| Cayman Chemical | 10964 | Eicosapentaenoyl Ethanolamide ≥98% | 109001-03-8 | 100mg | $834 | 2024-03-01 | Buy |
Eicosapentaenoyl Ethanolamide Chemical Properties,Uses,Production
Uses
Eicosapentaenoyl Ethanolamide inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.
Definition
ChEBI: (5Z,8Z,11Z,14Z,17Z)-icosapentaenoylethanolamine is an N-acylethanolamine 20:5 that is the ethanolamide of (5Z,8Z,11Z,14Z17Z)-eicosapentaenoic acid. It has a role as a PPARgamma agonist. It is an endocannabinoid and a N-acylethanolamine 20:5. It is functionally related to an all-cis-5,8,11,14,17-icosapentaenoic acid.
Biological Activity
Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator th at has been found to suppress lifespan extension resulting from dietary restriction in C. elegans and also to have antiproliferative and anti-inflammatory actions. In C. elegans, it is believed to act as a metabolic signal th at couples nutrient availability with growth and lifespan. EPEA is a member of the N-acylethanolamines (NAEs), lipid-derived signaling molecules th at include the mammalian endocannabinoid arachidonoyl ethanolamide (AEA). In mammals, NAEs are believed to act primarily through cannabinoid receptors, although they can also interact with a variety of other targets, and EPEA has been shown to act as a CB1 and CB2 receptor agonist. However, C. elegans does not possess clear orthologues of the mammalian cannabinoid receptors which suggests th at there are unidentified NAE receptors in nematodes th at are possibly conserved mediators of NAE signaling.
Eicosapentaenoyl Ethanolamide Preparation Products And Raw materials
Raw materials
Preparation Products
Eicosapentaenoyl Ethanolamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
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