HMB-Val-Ser-Leu-VE
- CAS No.
- 862891-04-1
- Chemical Name:
- HMB-Val-Ser-Leu-VE
- Synonyms
- HMB-Val-Ser-Leu-VE;YQKMRGLFGXKLJC-VOSPOJDESA-N;L-Serinamide, N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]-
- CBNumber:
- CB42591274
- Molecular Formula:
- C26H39N3O7
- Molecular Weight:
- 505.6
- MDL Number:
- MOL File:
- 862891-04-1.mol
HMB-Val-Ser-Leu-VE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10007713 | HMB-Val-Ser-Leu-VE ≥98% | 862891-04-1 | 1mg | $71 | 2024-03-01 | Buy |
| Cayman Chemical | 10007713 | HMB-Val-Ser-Leu-VE ≥98% | 862891-04-1 | 5mg | $313 | 2024-03-01 | Buy |
| Cayman Chemical | 10007713 | HMB-Val-Ser-Leu-VE ≥98% | 862891-04-1 | 10mg | $554 | 2024-03-01 | Buy |
| Cayman Chemical | 10007713 | HMB-Val-Ser-Leu-VE ≥98% | 862891-04-1 | 25mg | $1210 | 2024-03-01 | Buy |
| ApexBio Technology | C4090 | HMB-Val-Ser-Leu-VE | 862891-04-1 | 1mg | $79 | 2021-12-16 | Buy |
HMB-Val-Ser-Leu-VE Chemical Properties,Uses,Production
Definition
ChEBI: N-(3-hydroxy-2-methylbenzoyl)-l-valyl-n-[(1s,2e)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-l-serinamide is a dipeptide.
Biological Activity
hmb-val-ser-leu-ve is an irreversible, cell-permeable, potent and specific inhibitor of the trypsin-like activity of the 20s proteasome with ic50 value of 33 nm [1].the 20s proteasome is a 700 kda, cylinder-shaped protease with multiple catalytic centers within the ubiquitin-proteasome pathway and plays an important role in the selective degradation of intracellular proteins. proteasomes remove abnormal proteins and play an important role in cell-cycle progression and apoptosis [1][2].hmb-val-ser-leu-ve is a tripeptide-based compound bearing a c-terminal vinyl ester that acts as a potent and selective inhibitor of the trypsin-like activity of the 20s proteasome with ic50 value of 33 nm [1]. in two colon-carcinoma cell lines (coo115, hct116), hmb-val-ser-leu-ve was nontoxic and did not affect cell proliferation. in hla-a2 positive lymphoblastoid cells, hmb-val-ser-leu-ve caused a dose-dependent increase of clg-specific killing, suggesting that hmb-val-ser-leu-ve favored the generation and presentation of immunogenic peptides presented by mhc class i molecules [1].
References
[1]. marastoni m, baldisserotto a, cellini s, et al. peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity. j med chem. 2005 jul 28;48(15):5038-42.
[2]. demartino gn, slaughter ca. the proteasome, a novel protease regulated by multiple mechanisms.
HMB-Val-Ser-Leu-VE Preparation Products And Raw materials
Raw materials
Preparation Products
HMB-Val-Ser-Leu-VE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| ApexBio Technology | 58 |