5-BroMo-1,2,3-triazine
- CAS No.
- 114078-88-5
- Chemical Name:
- 5-BroMo-1,2,3-triazine
- Synonyms
- 5-bromotriazine;5-BroMo-1,2,3-triazine;1,2,3-Triazine, 5-bromo-
- CBNumber:
- CB42595757
- Molecular Formula:
- C3H2BrN3
- Molecular Weight:
- 159.97
- MDL Number:
- MFCD13193660
- MOL File:
- 114078-88-5.mol
- MSDS File:
- SDS
| Melting point | 112 °C (decomp)(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 242.5±32.0 °C(Predicted) |
| Density | 1.875±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | -1.31±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| InChI | InChI=1S/C3H2BrN3/c4-3-1-5-7-6-2-3/h1-2H |
| InChIKey | LSBKXRBABHPHBW-UHFFFAOYSA-N |
| SMILES | N1C=C(Br)C=NN=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H332-H302-H335-H319-H315 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501 |
5-BroMo-1,2,3-triazine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B416743 | 5-Bromo-1,2,3-triazine | 114078-88-5 | 2.5mg | $45 | 2021-12-16 | Buy |
| TRC | B416743 | 5-Bromo-1,2,3-triazine | 114078-88-5 | 5mg | $65 | 2021-12-16 | Buy |
| AK Scientific | 0191CV | 5-Bromo-1,2,3-triazine | 114078-88-5 | 50mg | $254 | 2021-12-16 | Buy |
| AK Scientific | 0191CV | 5-Bromo-1,2,3-triazine | 114078-88-5 | 100mg | $328 | 2021-12-16 | Buy |
| Crysdot | CD11347687 | 5-Bromo-1,2,3-triazine 97% | 114078-88-5 | 250mg | $388 | 2021-12-16 | Buy |
5-BroMo-1,2,3-triazine Chemical Properties,Uses,Production
Synthesis
122481-11-2
114078-88-5
The general procedure for the synthesis of 5-bromo-1,2,3-triazine using 4-bromo-1H-pyrazol-1-amine as starting material was as follows: dichloromethane (200 mL) and water (76 mL) were added to a reaction flask, and the mixture was cooled to 0 °C with stirring. Subsequently, sodium periodate (29.4 g, 137 mmol) was added in batches. After the addition was completed, the reaction mixture was continued to be stirred at 0°C for 12 hours. After completion of the reaction, the mixture was warmed up to 25 °C for partitioning operation. The aqueous phase was extracted with dichloromethane (100 mL x 3) and all organic phases were combined. The organic phase was washed with saturated brine (250 mL) and then dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether: ethyl acetate= 10:1), and finally 5-bromo-1,2,3-triazine was obtained as a white solid (8.8 g, two-step overall yield 73.5%).
References
[1] Liebigs Annalen der Chemie, 1993, # 4, p. 367 - 374
[2] Chemical & Pharmaceutical Bulletin, 1988, vol. 36, # 10, p. 3838 - 3848
[3] Journal of the American Chemical Society, 2011, vol. 133, # 31, p. 12285 - 12292
[4] Patent: CN105884752, 2016, A. Location in patent: Paragraph 0211; 0212; 0213
[5] Patent: WO2017/35353, 2017, A1. Location in patent: Paragraph 0928
5-BroMo-1,2,3-triazine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-BroMo-1,2,3-triazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13014 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd | 13005928603 | 211017228@qq.com | China | 7225 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2295 | 58 |
| Chemfun Medical Technology(Shanghai) Co., Ltd. | 021-67220633 021-54824098 | chemfun@chemfun.net | China | 491 | 58 |