Asenapine-13C-D3 hydrochloride
- CAS No.
- 1261392-55-5
- Chemical Name:
- Asenapine-13C-D3 hydrochloride
- Synonyms
- 2H3]-Asenapine hydrochloride;Asenapine-13C-D3 hydrochloride;[13C,2H3]-Asenapine hydrochloride;(3aR,12bR)-5-Chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride
- CBNumber:
- CB42610111
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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Asenapine-13C-D3 hydrochloride Chemical Properties,Uses,Production
Biological Activity
(±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic.1,2 It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).2 (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine , respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).1 In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.3 It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.4 Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
References
1.Ghanbari, R., El Mansari, M., Shahid, M., et al.Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, α2-adrenergic and D2 receptors in the rat brainEur. Neuropsychopharmacol.19(3)177-187(2009) 2.Shahid, M., Walker, G.B., Zorn, S.H., et al.Asenapine: A novel psychopharmacologic agent with a unique human receptor signatureJ. Psychopharmacol.23(1)65-73(2009) 3.Fr?nberg, O., Wiker, C., Marcus, M.M., et al.Asenapine, a novel psychopharmacologic agent: Preclinical evidence for clinical effects in schizophreniaPsychoparmacol.(Berl).196(3)417-429(2008) 4.McLean, S.L., Neill, J.C., Idris, N.F., et al.Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the ratBehav. Brain Res.214(2)240-247(2010)
Asenapine-13C-D3 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Asenapine-13C-D3 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Manhag Testing Technology Co., Ltd | 020-020-3846236 17688849268 | 2443244976@qq.com | China | 7775 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8747 | 58 |
| guoyungurui | 18162595016 | 3287908757@qq.com | China | 10338 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | tech@zzbioco.com | China | 12064 | 58 |
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