[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)-
- CAS No.
- 886578-07-0
- Chemical Name:
- [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)-
- Synonyms
- APOG2;Apogossypolone;Apogossypolone (ApoG2);Gossypol Derivative ApoG2;[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)-
- CBNumber:
- CB42624374
- Molecular Formula:
- C28H26O8
- Molecular Weight:
- 490.5
- MDL Number:
- MOL File:
- 886578-07-0.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A727400 | Apogossypolone | 886578-07-0 | 2.5mg | $120 | 2021-12-16 | Buy |
ApexBio Technology | A4200 | Apogossypolone(ApoG2) | 886578-07-0 | 25mg | $2000 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0002665 | 6,6',7,7'-TETRAHYDROXY-5,5'-DIISOPROPYL-3,3'-DIMETHYL-[2,2'-BINAPHTHALENE]-1,1',4,4'-TETRAONE 95.00% | 886578-07-0 | 5MG | $495.81 | 2021-12-16 | Buy |
ApexBio Technology | A4200 | Apogossypolone(ApoG2) | 886578-07-0 | 5mg | $700 | 2021-12-16 | Buy |
Chemenu | CM140057 | 6,6'',7,7''-tetrahydroxy-5,5''-diisopropyl-3,3''-dimethyl-[2,2''-binaphthalene]-1,1'',4,4''-tetraone 95% | 886578-07-0 | 1g | $931 | 2021-12-16 | Buy |
[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Chemical Properties,Uses,Production
Uses
Apogossypolone is an anticancer agent that induces apoptosis in carcinoma cells. Antiproliferative.
Biological Activity
apogossypolone is an inhibitor of bcl-2, mcl-1 and bcl-xl with ki values of 35nm, 25nm and 660nm, respectively [1].the mtt-based cell cytotoxicity assay shows that apogossypolone has an anticancer activity with ic50 values of 1, 2 and 3μm, respectively in pc-3, du-145 (human prostate cancer cell lines) and mda-mb-231(human breast cancer cell line). apogossypolone is also found to inhibit the colony formation of du-145 cells. the mechanism is that apogossypolone binds to bcl-2 and prevents its association with bh3-only pro-apoptotic proteins, leading the pro-apoptotic proteins to participate in the apoptotic response [2].besides prostate cancer and breast cancer, apogossypolone is also potent in follicular lymphoma. apogossypolone significantly inhibits the cell growth via inducing apoptosis in wsu-fsccl cell line with ic50 value of 109.2nm at 72h [3].
target
Bcl-2
References
[1] zhang xq, huang xf, hu xb, zhan yh, an qx, yang sm, xia aj, yi j, chen r, mu sj, wu dc. apogossypolone, a novel inhibitor of antiapoptotic bcl-2 family proteins, induces autophagy of pc-3 and lncap prostate cancer cells in vitro. asian j androl. 2010 sep;12(5):697-708.
[2] zhan y, jia g, wu d, xu y, xu l. design and synthesis of a gossypol derivative with improved antitumor activities. arch pharm (weinheim). 2009 apr;342(4):223-9.
[3] arnold aa, aboukameel a, chen j, yang d, wang s, al-katib a, mohammad rm. preclinical studies of apogossypolone: a new nonpeptidic pan small-molecule inhibitor of bcl-2, bcl-xl and mcl-1 proteins in follicular small cleaved cell lymphoma model. mol cancer. 2008 feb 14;7:20.
[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2231 | 55 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |