ChemicalBook >> CAS DataBase List >>CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
- CAS No.
- 66592-89-0
- Chemical Name:
- CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
- Synonyms
- Kevetrin HCl;KEVETRIN, NSC 525990;Kevetrin (hydrochloride);Thioureidobutyronitrile HCl;Kevetrin hydrochloride, >98%;3-cyanopropyl carbamimidothioate;Kevetrin hydrochloride >=98% (HPLC);Thioureidobutyronitrile hydrochloride;Kevetrin hydrochloride, 10 mM in DMSO;4-Isothioureidobutyronitrile hydrochloride
- CBNumber:
- CB42624925
- Molecular Formula:
- C5H10ClN3S
- Molecular Weight:
- 179.67
- MDL Number:
- MOL File:
- 66592-89-0.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
| Melting point | 125-127 °C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility |
DMSO:38.0(Max Conc. mg/mL);211.5(Max Conc. mM) Water:36.0(Max Conc. mg/mL);200.37(Max Conc. mM) Ethanol:21.0(Max Conc. mg/mL);116.88(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);55.66(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| Water Solubility | H2O: 2mg/mL, clear |
| FDA UNII | NL6L2371DP |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2184 | Kevetrin hydrochloride ≥98% (HPLC) | 66592-89-0 | 5mg | $102 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2184 | Kevetrin hydrochloride ≥98% (HPLC) | 66592-89-0 | 25mg | $329 | 2024-03-01 | Buy |
| Cayman Chemical | 28288 | Kevetrin (hydrochloride) | 66592-89-0 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 28288 | Kevetrin (hydrochloride) | 66592-89-0 | 10mg | $104 | 2024-03-01 | Buy |
| Cayman Chemical | 28288 | Kevetrin (hydrochloride) | 66592-89-0 | 25mg | $225 | 2024-03-01 | Buy |
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) Chemical Properties,Uses,Production
Uses
4-Isothioureidobutyronitrile-13C2, 15N3 Hydrochloride acts as a reagent in the synthesis of nitrile derivatives and their pharmaceutical uses and compositions.
Biological Activity
Kevetrin is an activator/stabilizer of wild type p53 tumor suppressor protein in human lung carcinoma and ovarian cancer cells th at induces cell cycle arrest and apoptosis. Additionally Kevetrin down-regulates oncogenic mutant p53 in OVCAR-3 ovarian cancer cells. Kevetrin inhibits tumor growth in xenograft model of ovarian cancer.
in vivo
Kevetrin hydrochloride (150-200 mg/kg; i.p.; 20 d) induces ~40% cell death in OV-90 or OVCAR-3 xenograft tumors, also inhibits tumor growth and extents survival time of mice with tumor xenograft mode[2].
| Animal Model: | A2780 xenograft tumor model in nude mice[2] |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection; 3 times per week, for 20 days |
| Result: | Inhibited tumor growth and suppressed the tumor volume. |
| Animal Model: | SKOV-3 xenograft ascites model in mice[2] |
| Dosage: | 150 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Prolonged the survival time of mice, and maintained 100% survival rate more over 35 days. |
Synthesis of CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) from 4-Chlorobutyronitrile and Carbamimidothioic acid
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) Preparation Products And Raw materials
Global( 82)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20234 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Kevetrin hydrochloride
66592-89-0
|
US $38.00-113.00 / mg | 99.38% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
66592-89-0
|
US $1.00 / KG | 1KG | 95%~99% | per week:100kg | Career Henan Chemical Co |
-
- Kevetrin hydrochloride
66592-89-0
- US $38.00-113.00 / mg
- 99.38%
- TargetMol Chemicals Inc.
-
- CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
66592-89-0
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)
Kevetrin HCl
Kevetrin (hydrochloride)
3-cyanopropyl carbamimidothioate
KEVETRIN, NSC 525990
3-cyanopropyl carbamimidothioate,hydrochloride
Thioureidobutyronitrile hydrochloride
3-Cyanopropyl carbamimidothioate hydrochloride (1:1)
Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride
Kevetrin hydrochloride, >98%
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1
4-Isothioureidobutyronitrile hydrochloride
Thioureidobutyronitrile HCl
Kevetrin hydrochloride >=98% (HPLC)
TP53 wild-type,preferential cytotoxic activity,4-Isothioureidobutyronitrile,Inhibitor,inhibit,blast cells,MOLM-13,thioureidobutyronitrile,Kevetrin,thioureido butyronitrile,Kevetrin hydrochloride,myeloid leukemia,MDM-2/p53,KASUMI-1,mutant primary
Kevetrin hydrochloride, 10 mM in DMSO
66592-89-0