4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide
- CAS No.
- 155836-50-3
- Chemical Name:
- 4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide
- Synonyms
- 4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide;Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-hydroxyphenyl)methyl]-N,N-diethyl-
- CBNumber:
- CB42670452
- Molecular Formula:
- C27H37N3O2
- Molecular Weight:
- 435.6
- MDL Number:
- MFCD09027343
- MOL File:
- 155836-50-3.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B820033 | BW373U86 | 155836-50-3 | 2.5mg | $415 | 2021-12-16 | Buy |
ApexBio Technology | B5157 | BW373U86 | 155836-50-3 | 10mg | $465 | 2021-12-16 | Buy |
Alichem | 155836503 | 4-((R)-((2s,5r)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-n,n-diethylbenzamide | 155836-50-3 | 50mg | $608.44 | 2021-12-16 | Buy |
Alichem | 155836503 | 4-((R)-((2s,5r)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-n,n-diethylbenzamide | 155836-50-3 | 250mg | $1757.46 | 2021-12-16 | Buy |
4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide Chemical Properties,Uses,Production
Uses
BW 373U86 is a δ opioid receptor-?selective racemic agonist.
Definition
ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.
Biological Activity
ki: 1.8, 15, 85 and 34 nm for delta, mu, epsilon and kappa receptoropioid receptors are heterogeneous and at least four types, mu,.delta, kappa and epsilon, are known to exist. currently, all clinically used opiates act through the mu receptor to induce analgesia; however, they also induce unwanted side effects such as respiratory depression, dependence, constipation and muscle rigidity.bw 373u86 is a novel, potent and selective nonpeptidic delta opioid receptor agonist.
in vitro
bw 373u86 was a potent delta receptor-selective ligand in receptor binding assays. the ki values were 1 .8 ± 0.4, 15 ± 3, 85 ± 4 and 34 ± 3 nm for delta, mu, epsilon and kappa receptor binding sites, respectively. bw 373u86 inhibited electncally evoked muscle contraction of mouse vas deferens with an ed50 value of 0.2 ± 0.06 nm [1].
in vivo
bw 373u86 inhibited the acoustic startle reflex after subcutaneous administration from 0.2- to 2-mg/kg doses in rats, and this inhibition was blocked by naltnndole. bw 373u86 also induced a dose-dependent increase of locomotor activity in rats at similar doses. this effect was inhibited by naltnndole [3].
storage
Store at +4°C
References
[1] chang kj, rigdon gc, howard jl, mcnutt rw. a novel, potent and selective nonpeptidic delta opioid receptor agonist bw 373u86. j pharmacol exp ther. 1993 nov;267(2):852-7.
4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
4-((R)-((2S,5R)-4-allyl-2,5-diMethylpiperazin-1-yl)(3-hydroxyphenyl)Methyl)-N,N-diethylbenzaMide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4455 | 58 |
Shanghai Chengrui Biotechnology Co., Ltd | 15316859367 | 2472126714@qq.com | China | 306 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
BOC Sciences | 65 |
TargetMol Chemicals Inc. | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 58 |
Shanghai Chengrui Biotechnology Co., Ltd | 58 |
ApexBio Technology | 58 |