ChemicalBook >> CAS DataBase List >>4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- structure

CAS No.: 402855-07-6

Chemical Name:: 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

Synonyms: Afatinib M;6-Nitro-4-[(3-chloro-4-fluorophenyl)amino]-7-[(R)-(tetrahydr...;N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3R)-oxolan-3-yl]oxyquinazolin-4-amine;4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-;(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine (Afatinib Impurity);Afatinib impurity 20/4-QuinazolinaMine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

CBNumber:: CB42694007

Molecular Formula:: C18H14ClFN4O4

Molecular Weight:: 404.78

MDL Number:

MOL File:: 402855-07-6.mol

Last updated:2023-05-15 10:43:33

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4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- Chemical Properties,Uses,Production

Uses

(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine is an intermediate used in the preparation of afatinib ant it’s impurities. Afatinib(A355300) is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10978	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
BeiJing Hwrk Chemicals Limted	0757-86329057 18934348241	sales4.gd@hwrkchemical.com	China	14067	55
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Taizhou Tongxin Bio-Tech Co., Ltd	0523-18601685-898 18652728585	sales@allyrise.com	China	2773	60
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18018	56
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10287	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9874	58

Supplier	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Amadis Chemical Company Limited	58
BeiJing Hwrk Chemicals Limted	55
BOC Sciences	65
Taizhou Tongxin Bio-Tech Co., Ltd	60
ChemStrong Scientific Co.,Ltd	56
Shanghai YuLue Chemical Co., Ltd.	55
BOC Sciences	65
Shanghai Chaolan Chemical Technology Center	58

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- Afatinib impurity 20/4-QuinazolinaMine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]- N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3R)-oxolan-3-yl]oxyquinazolin-4-amine Afatinib M (R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine (Afatinib Impurity) 6-Nitro-4-[(3-chloro-4-fluorophenyl)amino]-7-[(R)-(tetrahydr... 402855-07-6