(αR,βS)-rel-Bedaquiline
- CAS No.
- 654653-93-7
- Chemical Name:
- (αR,βS)-rel-Bedaquiline
- Synonyms
- Glycerol Impurity 108;Bedaquiline (1R,2S)Isomer;(AlphaR,BetaS)-rel-Bedaquiline;Bedaquiline Fumarate Impurity 40;cis-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;(αR,βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol;(1R,2S)-rac-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αR,βS)-rel-
- CBNumber:
- CB42694663
- Molecular Formula:
- C32H31BrN2O2
- Molecular Weight:
- 555.5
- MDL Number:
- MOL File:
- 654653-93-7.mol
| Melting point | >180°C (dec.) |
|---|---|
| Boiling point | 702.7±60.0 °C(Predicted) |
| Density | 1.322±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 13.05±0.29(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
(αR,βS)-rel-Bedaquiline price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B119555 | (αR,βS)-rel-Bedaquiline | 654653-93-7 | 10mg | $130 | 2021-12-16 | Buy |
| TRC | B119555 | (αR,βS)-rel-Bedaquiline | 654653-93-7 | 25mg | $250 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 49651 | (αR,βS)-rel-Bedaquiline | 654653-93-7 | 50mg | $2200 | 2021-12-16 | Buy |
(αR,βS)-rel-Bedaquiline Chemical Properties,Uses,Production
Chemical Properties
Off-white Solid
Uses
(αR,βS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (αR,βS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis.
Definition
ChEBI: Bedaquiline is a quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. It has a role as an antitubercular agent and an ATP synthase inhibitor. It is a member of quinolines, a member of naphthalenes, an organobromine compound, an aromatic ether, a tertiary alcohol and a tertiary amino compound. It is a conjugate base of a bedaquiline(2+).
(αR,βS)-rel-Bedaquiline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4505 | 50 | |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |
| Chengdu Miracle Pharmaceutical Co., Ltd. | 028-86136736 19130631884 | sales@mic-pharma.com | China | 276 | 56 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 5534 | 58 |
| Alchemist-pharm chemical Technology Co. Ltd. | 0371-67991738 13783628208 | carl@alchemist-pharm.com | China | 1877 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |