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OLIGOMYCIN A

OLIGOMYCIN A Structure
OLIGOMYCIN A structure
CAS No.
579-13-5
Chemical Name:
OLIGOMYCIN A
Synonyms
OLIGOMYCIN COMPLEX;CS-1898;Oli;MCH 32;mycin A;AOligoMyci;OLIGOMYCIN A;Oligomycin A, >=98%;Oligomycin A MCH 32;OLIGOMYCIN A USP/EP/BP
CBNumber:
CB4274065
Molecular Formula:
C45H74O11
Molecular Weight:
791.06
MDL Number:
MFCD00065705
MOL File:
579-13-5.mol
MSDS File:
SDS
Last updated:2024-11-17 19:25:39
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OLIGOMYCIN A Properties

Melting point 150-151℃
Boiling point 886.3±65.0 °C(Predicted)
Density 1.14
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO, ethanol or acetone
pka 12.52±0.70(Predicted)
form powder
color white to off-white
Merck 13,6902
BRN 5702132
InChIKey MNULEGDCPYONBU-WMBHJXFZSA-N
EWG's Food Scores 1
FDA UNII 05HQS4AI99

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn,T
Risk Statements  22-68/20/21/22-20/21/22
Safety Statements  36/37-24/25
RIDADR  2811
WGK Germany  3
RTECS  RK3325000
F  3-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
NFPA 704
0
2 0

OLIGOMYCIN A price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 75351 Oligomycin A ≥95% (HPLC) 579-13-5 5mg $198 2024-03-01 Buy
Cayman Chemical 11342 Oligomycin A ≥95% 579-13-5 1mg $56 2024-03-01 Buy
Cayman Chemical 11342 Oligomycin A ≥95% 579-13-5 5mg $135 2024-03-01 Buy
Cayman Chemical 11342 Oligomycin A ≥95% 579-13-5 10mg $241 2024-03-01 Buy
Cayman Chemical 11342 Oligomycin A ≥95% 579-13-5 25mg $362 2024-03-01 Buy
Product number Packaging Price Buy
75351 5mg $198 Buy
11342 1mg $56 Buy
11342 5mg $135 Buy
11342 10mg $241 Buy
11342 25mg $362 Buy

OLIGOMYCIN A Chemical Properties,Uses,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.

Chemical Properties

White powder

Uses

Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Uses

Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumour and nematocidal activities.

Uses

Oligomycin A is a macrolide with fungicidal activity isolated from Streptomyces species.

storage

-20°C

References

[1]. jastroch m, divakaruni as, mookerjee s, et al. mitochondrial proton and electron leaks. essays biochemistry, 2010, 47:53-67.
[2]. shchepina la, pletjushkina oy, avetisyan av, et al. oligomycin, inhibitor of the f-0 part of h+-atp-synthase, suppresses the tnf-induced apoptosis. oncogene, 2002, 53: 8149-8157.
[3]. salomon ar, voehringer dw, herzenberg la, et al. understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of f0f1-atpase. proceedings of the national academy of sciences of the united states of america, 2000, 97(26): 14766-14771.
[4]. alexander r, adina v, ivan b,　et al. overcoming intrinsic multi-drug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling jarid1bhigh cells. cancer cell, 2013, 23(6): 811-825.

OLIGOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

OLIGOMYCIN A Suppliers

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		China 11415 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
ZHEJIANG JIUZHOU CHEM CO., LTD 		+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 12272 58
Supplier Advantage
BOC Sciences 		58
career henan chemical co 		58
Hubei Ipure Biology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Finetech Industry Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Henan Alfa Chemical Co., Ltd 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ZHEJIANG JIUZHOU CHEM CO., LTD 		58

View Lastest Price from OLIGOMYCIN A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Oligomycin A pictures 2024-11-17 Oligomycin A
579-13-5
 US $128.00-211.00 / mg 99.86% 10g TargetMol Chemicals Inc.
OLIGOMYCIN A pictures 2019-12-23 OLIGOMYCIN A
579-13-5
 US $1.00 / g 100g 99% G/KG/T Career Henan Chemical Co
  • Oligomycin A pictures
  • Oligomycin A
    579-13-5
  • US $128.00-211.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.
  • OLIGOMYCIN A pictures
  • OLIGOMYCIN A
    579-13-5
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

OLIGOMYCIN A Spectrum

OLIGOMYCIN A(579-13-5)1HNMR

579-13-5(OLIGOMYCIN A)Related Search:

citreoviridin LIPOPOLYSACCHARIDE FROM ESCHERICHIA COLI Glutathione Everolimus Y27632 (hydrochloride)
Selumetinib MG-132 Trametinib CHIR-99021 OLIGOMYCIN B,Oligomycin A, 28-oxo- ,OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES,Oligomycin B fromStreptomyces diastatochromogenes
oligomycin D OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN C,Oligomycin A, 12-deoxy- OLIGOMYCIN oligomycin E OLIGOMYCIN A,OLIGOMYCIN COMPLEX,OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES
oligomycin G Oligomycin F oligomycin sensitivity-conferring protein

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OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES OLIGOMYCIN A OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES Oligomycin A fromStreptomyces diastatochromogenes (1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione (1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonaMethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonaco MCH 32 AOligoMyci mycin A Oli Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16 Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)- Oligomycin A MCH 32 Oligomycin A, >=98% Oligomycin A, 99%, from Streptomyces diastatochromogenes Oligomycin A from Streptomyces OLIGOMYCIN A USP/EP/BP (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-((R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-2,26-dioxaspiro[bicyclo[23.3.1]nonacosa[4,18,20]triene-27,2'-pyran]-3,9,13-trione (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-((R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-2,26-dioxaspiro[bicyclo[23.3.1]nonacosa[4,18,20]triene-27,2'- OLIGOMYCIN COMPLEX CS-1898 (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-((R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-2,26-dioxaspiro[bicyclo[23.3.1]nonacosa[4,18,20]triene-27,2'-pyran]-3,9,13-trione Oligomycin A, ATP synthase inhibitor 579-13-5 Antibiotics Antibiotics N-S Antibiotics A to Z BioChemical Inhibitors antibiotic Antibiotics AntifungalAntibiotics Antineoplastic and Immunosuppressive AntibioticsAntibiotics Inhibits an EnzymeAntibiotics Antibiotics A to Antibiotics by Application Antibiotics N-SAntibiotics Chemical Structure Class Macrolides Mechanism of Action Spectrum of Activity API