CAS:932749-62-7
- CAS No.
- 932749-62-7
- Chemical Name:
- CAS:932749-62-7
- Synonyms
- CAS:932749-62-7;HAT Inhibitor II;Histone Acetyltransferase Inhibitor II;Histone Acetyltransferase Inhibitor II (compound 2c);Histone Acetyltransferase Inhibitor II, 10 mM in DMSO;2,6-Bis(3-bromo-4-hydroxybenzylidene)cyclohexan-1-one;2,6-Bis[(3-bromo-4-hydroxyphenyl)methylene]cyclohexanone;Cyclohexanone, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-;Histone Acetyltransferase Inhibitor II, p300/CBP HAT inhibitor;Histone Acetyltransferase,HeLa,H2B-EYFP,acetylation,inhibit,Histone Acetyltransferase Inhibitor II,HAT,anti-acetylase,Inhibitor,HATs,histones
- CBNumber:
- CB42741611
- Molecular Formula:
- C20H16Br2O3
- Molecular Weight:
- 464.15
- MDL Number:
- MFCD11655778
- MOL File:
- 932749-62-7.mol
- MSDS File:
- SDS
| Melting point | 201-202 °C(Solv: isopropanol (67-63-0); water (7732-18-5)) |
|---|---|
| Boiling point | 580.8±50.0 °C(Predicted) |
| Density | 1.733±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 7.89±0.35(Predicted) |
| color | Light yellow to yellow |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
CAS:932749-62-7 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 10mg | $213 | 2024-03-01 | Buy |
| Usbiological | 451941 | Histone Acetyltransferase Inhibitor II | 932749-62-7 | 10mg | $516 | 2021-12-16 | Buy |
| TRC | H456345 | HistoneAcetyltransferaseInhibitorII | 932749-62-7 | 25mg | $400 | 2021-12-16 | Buy |
CAS:932749-62-7 Chemical Properties,Uses,Production
Uses
Histone Acetyltransferase Inhibitor II is a selective, cell-permeable p300/CBP HAT inhibitor, which may be used in the treatement of cystic fibrosis.
Biological Activity
hat inhibitor ii, a cell-permeable bis-arylidene cyclohexanone compound, selectively inhibits the histone acetyltransferase p300/creb-binding protein (cbp) with an ic50 value of 5 μm. it affects gcn5 and pcaf acetyltransferases only at much higher concentrations.histone acetyltransferase p300, a ubiquitously expressed global transcriptional coactivator, plays critical roles in a wide variety of cellular phenomena, involving in cell cycle control, differentiation, and apoptosis.
in vitro
hat inhibitor ii dose-dependently suppressed the proliferation of u251, u87, hs683 and shg44 cells. in hat inhibitor ii-treated u251 and shg44 cells, cell cycle arrest at the g2/m phase was triggered by hat inhibitor ii, significant levels of apoptosis, apoptotic body formation and dna fragmentation were induced, and cleavage of caspase-3, caspase-9 and parp were caused. additionally, hat inhibitor ii upregulated 965 genes and downregulated 984 genes in hat inhibitor ii-treated u251 cells [1].
in vivo
c57bl/6j mice were intraperitoneally administrated with hat inhibitor ii at a dose of 185 μg/g for 15 min. in muscle early postmortem, hat inhibitor ii inhibited protein acetylation, which reduced amp-activated protein kinase activation induced increase in the total acetylated proteins as well as glycolytic rate [2].
IC 50
CBP/p300
References
[1]. xu, l., li, z., tao, y., li, r., fang, f., & zhao, h. et al. histone acetyltransferase inhibitor ii induces apoptosis in glioma cell lines via the p53 signaling pathway. journal of experimental & clinical cancer research. 2014; 33:108.
[2]. li, q., li, z., lou, a., wang, z., zhang, d., & shen, q. histone acetyltransferase inhibitors antagonize amp-activated protein kinase in postmortem glycolysis. asian-australasian journal of animal sciences. 2016; 30(6): 857-864.
CAS:932749-62-7 Preparation Products And Raw materials
Raw materials
Preparation Products
CAS:932749-62-7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10123 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19915 | 55 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 825 | 58 |
View Lastest Price from CAS:932749-62-7 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | Histone Acetyltransferase Inhibitor II
932749-62-7
|
US $30.00-98.00 / mg | 97.13% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-17 | Histone Acetyltransferase Inhibitor II
932749-62-7
|
US $30.00-98.00 / mg | 97.13% | 10g | TargetMol Chemicals Inc. |
-
- Histone Acetyltransferase Inhibitor II
932749-62-7
- US $30.00-98.00 / mg
- 97.13%
- TargetMol Chemicals Inc.
-
- Histone Acetyltransferase Inhibitor II
932749-62-7
- US $30.00-98.00 / mg
- 97.13%
- TargetMol Chemicals Inc.