4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- CAS No.
- 1421312-34-6
- Chemical Name:
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- Synonyms
- methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxastat intermediate;Roxadustat Impurity 34;Roxadustat impurity rst3;Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate
- CBNumber:
- CB42756260
- Molecular Formula:
- C18H15NO4
- Molecular Weight:
- 309.32
- MDL Number:
- MFCD30489347
- MOL File:
- 1421312-34-6.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H302-H315-H335 |
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
AK Scientific | 2731DU | Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate | 1421312-34-6 | 5g | $593 | 2021-12-16 | Buy |
Alichem | 1421312346 | Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate | 1421312-34-6 | 10g | $614.8 | 2021-12-16 | Buy |
Crysdot | CD11260325 | Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 97% | 1421312-34-6 | 1g | $120 | 2021-12-16 | Buy |
Chemenu | CM263516 | Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 95+% | 1421312-34-6 | 5g | $337 | 2021-12-16 | Buy |
Crysdot | CD11260325 | Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 97% | 1421312-34-6 | 5g | $360 | 2021-12-16 | Buy |
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.
Preparation
Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 | lvan.hui@jsytsw.com | China | 80 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3389 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 | sales@jinghaopharma.com | CHINA | 153 | 58 |
View Lastest Price from 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Roxadustat Impurity 26
1421312-34-6
|
US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2023-11-01 | 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester
1421312-34-6
|
US $0.00 / kg | 1kg | 99% | 200kg | Hangzhou ICH Biofarm Co., Ltd | ||
2022-10-14 | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
1421312-34-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
- Roxadustat Impurity 26
1421312-34-6
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester
1421312-34-6
- US $0.00 / kg
- 99%
- Hangzhou ICH Biofarm Co., Ltd
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
1421312-34-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.