Felodipine | 72509-76-3

Felodipine Properties

Melting point	142-145°C
Boiling point	471.5±45.0 °C(Predicted)
Density	1.3506 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	DMSO: 28 mg/mL
form	solid
pka	2.73±0.70(Predicted)
color	light yellow
Water Solubility	insoluble
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI	InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey	RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference	72509-76-3(CAS DataBase Reference)
FDA UNII	OL961R6O2C
NIST Chemistry Reference	Felodipine(72509-76-3)
ATC code	C08CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 3077 9 / PGIII

WGK Germany

3

RTECS

US7968700

HS Code

29333990

NFPA 704

	0
3		0

Felodipine price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F9677	Felodipine solid	72509-76-3	5mg	$131	2024-03-01	Buy
Sigma-Aldrich	BP777	Felodipine British Pharmacopoeia (BP) Reference Standard	72509-76-3	100MG	$229	2024-03-01	Buy
Sigma-Aldrich	BP758	Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard	72509-76-3	20MG	$251	2024-03-01	Buy
Sigma-Aldrich	1269389	Felodipine United States Pharmacopeia (USP) Reference Standard	72509-76-3	300mg	$436	2024-03-01	Buy
Sigma-Aldrich	BP758	Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard	72509-76-3	BP758	$246	2023-06-20	Buy

Product number	Packaging	Price	Buy
F9677	5mg	$131	Buy
BP777	100MG	$229	Buy
BP758	20MG	$251	Buy
1269389	300mg	$436	Buy
BP758	BP758	$246	Buy

Felodipine Chemical Properties,Uses,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

vasodilator, Ca channel blocker

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

1) Todd and Faulds, (1992)?Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs?44?251 2) Furukawa?et al. (1999)?Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther.?291?464

Felodipine synthesis

Synthesis of Felodipine from ETHYL 3-AMINOCROTONATE and Methyl acetoacetate and 2,3-Dichlorobenzaldehyde

Felodipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate Methyl acetoacetate 3-Amino-2-butenoic acid ethyl ester 2,3-Dichlorobenzaldehyde Isopropyl alcohol

Hydrochloric acid NeMadipine B Felodipine 3,5-DiMethyl Ester

1of2

Preparation Products

Felodipine Suppliers

Global( 506)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	287	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Jimi Trading Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from Felodipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-27	Felodipine 72509-76-3	US $0.00 / Kg/Drum	1KG	98%-101%	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-19	Felodipine 72509-76-3	US $47.00-126.00 / mg		100%	10g	TargetMol Chemicals Inc.
2024-11-19	Felodipine 72509-76-3	US $47.00-126.00 / mg		100%	10g	TargetMol Chemicals Inc.

Felodipine
72509-76-3
US $0.00 / Kg/Drum
98%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

Felodipine
72509-76-3
US $47.00-126.00 / mg
100%
TargetMol Chemicals Inc.

Felodipine
72509-76-3
US $47.00-126.00 / mg
100%
TargetMol Chemicals Inc.

Felodipine Spectrum

Felodipine(72509-76-3)¹HNMR

72509-76-3(Felodipine)Related Search:

ETHANE Dichlorodimethylsilane Dimethyl phthalate Amlodipine maleate Dimethyl carbonate

Amlodipine Dimethyl fumarate N,N-Dimethylformamide Dimethyl sulfoxide Dimethyl sebacate

(S)-Amlodipine Dichlorodiphenylsilane Chlorodimethylphenylsilane Amlodipine Besylate Dihydromyrcenol

Dimethyl ether Felodipine Metabolite Lactone DEHYDRO FELODIPINE-13C4

1of4

,ethylmethylester ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica 4-(2，3-Dichlorophenyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester Fjodil：Hydac P|endil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester CGH-869 Spendil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil Felodipine (300 mg) Felodipine (200 mg) Felodipine/Plendil 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Felodipine, USP Felodipine API 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Clevidipine Butyrate iMpurity Ⅱ 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester Cleviprex Impurity E Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester h154/82 modip 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester FelodipineUsp25DmfGmp 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil, (RS)-Felodipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester Agon dl-Felodipine Hydac Munobal Splendil Felodipine Felodipine (1269389) FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine Felodipine (CGH869) Felodipine USP/EP/BP Hot selling high quality Felodipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester odipine Felodipine> Felodipine CRS Felodipine, ≥98.0% Felodipine, 98%, Selective L-type Ca2+ channel blocker Clevidipine Butyrate Impurity 2 Felodipine, 98%, a selective L-type Ca2+ channel blocker Clevidipine Impurity E FEXOFENADINE HCL Felodipin Plendil Felodipine in methanol Felodipine in Acetonitrile 72509-76-3 72509-76-3;8618