Epacadostat (INCB024360)
- CAS No.
- 1204669-58-8
- Chemical Name:
- Epacadostat (INCB024360)
- Synonyms
- Epacadostat;CS-1617;INCB02436;INCN024360;(1204669-37-3);Epacadostat(INCB024360);INCB-24360(INCB-024360);Epacadostat(INCN024360);IDO inhibitor(INCB024360);INCB 024360 , Epacadostat
- CBNumber:
- CB43038482
- Molecular Formula:
- C11H13BrFN7O4S
- Molecular Weight:
- 438.23
- MDL Number:
- MFCD29075639
- MOL File:
- 1204669-58-8.mol
Melting point | 159 - 161°C |
---|---|
Boiling point | 700.9±70.0 °C(Predicted) |
Density | 2.01±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to at least 25 mg/ml) |
form | solid |
pka | 7.65±0.69(Predicted) |
color | White |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
FDA UNII | 71596A9R13 |
NCI Drug Dictionary | epacadostat |
ATC code | L01XX58 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H332-H302-H312 | |||||||||
Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
NFPA 704 |
|
Epacadostat (INCB024360) price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19875 | INCB024360 ≥98% | 1204669-58-8 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 19875 | INCB024360 ≥98% | 1204669-58-8 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 19875 | INCB024360 ≥98% | 1204669-58-8 | 10mg | $214 | 2024-03-01 | Buy |
Cayman Chemical | 19875 | INCB024360 ≥98% | 1204669-58-8 | 25mg | $494 | 2024-03-01 | Buy |
Usbiological | 474114 | Epacadostat | 1204669-58-8 | 10mg | $460 | 2021-12-16 | Buy |
Epacadostat (INCB024360) Chemical Properties,Uses,Production
Description
Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO). It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.
Uses
Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).
target
IDO1
References
1) Liu?et al.?(2010),?Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity;?Blood?115?3520 2) Koblish?et al.?(2010),?Hydroxyamidine Inhibitors of Indolamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors;?Mol. Cancer Ther.?9?489 3) Jochems?et al.?(2016),?The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells;?Oncotarget?7?37762 4) Yentz and Smith (2018),?Indoleamine-2,3-dioxygenase Inhibition as a Strategy to Augment Cancer Immunotherapy;?BioDrugs?32?311 5) Zhu??et al.?(2019),?Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development;?Curr. Oncol. Rep.?21?2 6) Mitchell?et al.?(2018),?Epacadostat Plus Pembrolizumab in Patients with Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037);?J. Clin. Oncol.?36?3223
Epacadostat (INCB024360) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19563 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from Epacadostat (INCB024360) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-19 | Epacadostat (INCB024360)
1204669-58-8
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | ||
2021-07-13 | INCB-24360;INCB24360
1204669-58-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2020-01-09 | Epacadostat (INCB024360)
1204669-58-8
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
- Epacadostat (INCB024360)
1204669-58-8
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
- INCB-24360;INCB24360
1204669-58-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Epacadostat (INCB024360)
1204669-58-8
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
1204669-58-8(Epacadostat (INCB024360))Related Search:
1of4