Hesperetin
- CAS No.
- 520-33-2
- Chemical Name:
- Hesperetin
- Synonyms
- (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908
- CBNumber:
- CB4304735
- Molecular Formula:
- C16H14O6
- Molecular Weight:
- 302.28
- MDL Number:
- MFCD00075646
- MOL File:
- 520-33-2.mol
- MSDS File:
- SDS
Melting point | 230-232°C |
---|---|
Boiling point | 363.32°C (rough estimate) |
Density | 1.2514 (rough estimate) |
refractive index | -4 ° (C=1.8, EtOH) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 7.49±0.40(Predicted) |
form | Solid |
color | White to Pale Yellow |
Water Solubility | Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml). |
Merck | 14,4670 |
BRN | 309850 |
InChIKey | AIONOLUJZLIMTK-AWEZNQCLSA-N |
LogP | 2.90 |
Substances Added to Food (formerly EAFUS) | 5,7-DIHYDROXY-2-(3-HYDROXY-4-METHXY-PHENYL)-CHROMAN-4-ONE |
CAS DataBase Reference | 520-33-2(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | Q9Q3D557F1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37/39-27-37 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29329990 | |||||||||
NFPA 704 |
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Hesperetin price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | H0721 | Hesperetin >97.0%(HPLC)(T) | 520-33-2 | 5g | $17 | 2024-03-01 | Buy |
TCI Chemical | H0721 | Hesperetin >97.0%(HPLC)(T) | 520-33-2 | 25g | $49 | 2024-03-01 | Buy |
Alfa Aesar | B20528 | 3',5,7-Trihydroxy-4'-methoxyflavanone, 97% | 520-33-2 | 1g | $30.65 | 2024-03-01 | Buy |
Alfa Aesar | B20528 | 3',5,7-Trihydroxy-4'-methoxyflavanone, 97% | 520-33-2 | 5g | $88.65 | 2024-03-01 | Buy |
Alfa Aesar | B20528 | 3',5,7-Trihydroxy-4'-methoxyflavanone, 97% | 520-33-2 | 25g | $345.65 | 2024-03-01 | Buy |
Hesperetin Chemical Properties,Uses,Production
Description
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.
Chemical Properties
Beige to Light Brown Crystalline Solid
Uses
antiallergic
Uses
The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.
Uses
(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Definition
ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).
Purification Methods
Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]
Hesperetin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 | info@staherb.cn | China | 1025 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2989 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 | angelia@hbmojin.com | China | 830 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3777 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from Hesperetin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-23 | Hesperetin
520-33-2
|
US $10.00 / kg | 1kg | 90%,95%,98%HPLC | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
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2024-08-23 | Hesperetin
520-33-2
|
US $100.00 / kg | 1kg | 98% | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
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2024-08-22 | Hesperetin
520-33-2
|
US $0.00-0.00 / kg | 1kg | 90%,95%,98% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Hesperetin
520-33-2
- US $10.00 / kg
- 90%,95%,98%HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Hesperetin
520-33-2
- US $100.00 / kg
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Hesperetin
520-33-2
- US $0.00-0.00 / kg
- 90%,95%,98%
- WUHAN FORTUNA CHEMICAL CO., LTD
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