ChemicalBook >> CAS DataBase List >>JH-II-127
JH-II-127
- CAS No.
- 1700693-08-8
- Chemical Name:
- JH-II-127
- Synonyms
- JH-II-127;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
- CBNumber:
- CB43049255
- Molecular Formula:
- C19H21ClN6O3
- Molecular Weight:
- 416.86
- MDL Number:
- MFCD28975160
- MOL File:
- 1700693-08-8.mol
Last updated:2023-09-20 16:43:00
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319 |
Precautionary statements | P261-P305+P351+P338 |
JH-II-127 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2569 | JH-II-127 ≥98% (HPLC) | 1700693-08-8 | 5MG | $123 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2569 | JH-II-127 ≥98% (HPLC) | 1700693-08-8 | 25MG | $396 | 2024-03-01 | Buy |
Cayman Chemical | 22905 | JH-II-127 | 1700693-08-8 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 22905 | JH-II-127 | 1700693-08-8 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 22905 | JH-II-127 | 1700693-08-8 | 10mg | $243 | 2024-03-01 | Buy |
JH-II-127 Chemical Properties,Uses,Production
Description
JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.
Uses
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.
storage
Store at -20°C
JH-II-127 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 70)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
JH-II-127
(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi
(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
2-anilino-4-methylamino-5-chloropyrrolopyrimidine
2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127
[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-
[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
1700693-08-8