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2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione structure

CAS No.: 835616-60-9

Chemical Name:: 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

Synonyms: 4-Fluoro-thalidomide;2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1,3-isoindolinedione;2-(2,6-Dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione;135582;TC-E3 5032;E3 ligase Ligand 4;Thalidomide 4-fluoride;Pomadomide impurity 30;E3 ligase Ligand 4(TC-E3 5032);Pomalidomide Related Compound 7

CBNumber:: CB43145029

Molecular Formula:: C13H9FN2O4

Molecular Weight:: 276.22

MDL Number:: MFCD11840666

MOL File:: 835616-60-9.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Properties

Melting point	254-256°C
Boiling point	520.9±45.0 °C(Predicted)
Density	1.570±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Dichloromethane (Slightly, Heated), DMSO (Slightly)
pka	10.63±0.40(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
InChIKey	CRAUTELYXAAAPW-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C(F)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H361-H302

Precautionary statements

P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501

HS Code

2933998090

NFPA 704

	0
2		0

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	26147	TC-E3 5032	835616-60-9	50mg	$106	2024-03-01	Buy
Cayman Chemical	26147	TC-E3 5032	835616-60-9	500mg	$261	2024-03-01	Buy
Cayman Chemical	26147	TC-E3 5032	835616-60-9	100mg	$137	2024-03-01	Buy
Cayman Chemical	26147	TC-E3 5032	835616-60-9	250mg	$233	2024-03-01	Buy
Tocris	6628	TCE35032 ≥98%(HPLC)	835616-60-9	100	$409	2021-12-16	Buy

Product number	Packaging	Price	Buy
26147	50mg	$106	Buy
26147	500mg	$261	Buy
26147	100mg	$137	Buy
26147	250mg	$233	Buy
6628	100	$409	Buy

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Chemical Properties,Uses,Production

Description

4-Fluoro-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

Uses

2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma.

Synthesis

A mixture of 4-fluoroisobenzofuran-l,3-dione (498.33 mg, 3.00 mmol), 3- aminopiperidine-2,6-dione hydrogen chloride (493.77 mg, 3.00 mmol) and NaOAc (246.09 mg, 3.00 mmol) in HOAc (10 mL) was stirred at 135 °C overnight, cooled and concentrated in vacuo. The residue was suspended in H2O (100 mL) and stirred at room temperature for 4 hours. The solid was collected via filtration and dried in vacuo to afford 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a white solid.

IC 50

Cereblon

storage

Store at +4°C

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Suppliers

Global( 184)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD	+8618627948422	sale@hdimpurity.com	China	3619	58
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19825	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1227	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2555	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58

Supplier	Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Shanghai finete Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Jinan Liheng Biotechnology Co., Ltd.	58

View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-27	Thalidomide 4-fluoride 835616-60-9	US $29.00 / mg		99.12%	10g	TargetMol Chemicals Inc.
2025-04-04	2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 835616-60-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2025-03-04	Pomalidomide Impurity 30 835616-60-9	US $0.00-0.00 / mg	10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD

Thalidomide 4-fluoride
835616-60-9
US $29.00 / mg
99.12%
TargetMol Chemicals Inc.

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
835616-60-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Pomalidomide Impurity 30
835616-60-9
US $0.00-0.00 / mg
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Spectrum

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione(835616-60-9)¹HNMR

835616-60-9(2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione)Related Search:

Cereblon Ligand 1 4-Hydroxy ThalidoMide Protein degrader 1 (TFA) (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione E3 ligase Ligand 4 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fl... Pomalidomide Related Compound 7 Thalidomide 4-fluoride TC-E3 5032 E3 ligase Ligand 4(TC-E3 5032) 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro- 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-1H-Isoindole-1,3(2H)-dione 135582 4-Fluoro-thalidomide 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1,3-isoindolinedione 2-(2,6-Dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione Pomadomide impurity 30 835616-60-9