ONO-8130
- CAS No.
- 459841-96-4
- Chemical Name:
- ONO-8130
- Synonyms
- ONO-8130;ONO-8130, 10 mM in DMSO;4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid;Benzoic acid, 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-;Orally active,ONO8130,Inhibitor,inhibit,Bladder pain,ONO 8130,Prostaglandin Receptor,Interstitial cystitis,PKR-like endoplasmic reticulum kinase,PERK,Hyperalgesia,Protein kinase R-like endoplasmic reticulum kinase,ONO-8130
- CBNumber:
- CB43152708
- Molecular Formula:
- C25H28N2O5S2
- Molecular Weight:
- 500.63
- MDL Number:
- MOL File:
- 459841-96-4.mol
ONO-8130 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19118 | ONO-8130 ≥98% | 459841-96-4 | 1mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 19118 | ONO-8130 ≥98% | 459841-96-4 | 5mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 19118 | ONO-8130 ≥98% | 459841-96-4 | 10mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 19118 | ONO-8130 ≥98% | 459841-96-4 | 25mg | $621 | 2024-03-01 | Buy |
| Tocris | 5406 | ONO8130 ≥98%(HPLC) | 459841-96-4 | 50 | $1081 | 2021-12-16 | Buy |
ONO-8130 Chemical Properties,Uses,Production
Uses
ONO 8130 is a selective prostanoid EP1 receptor antagonist, which relieves bladder pain in mice with cyclophosphamide-induced cystitis.
Biological Activity
ono-8130 is an orally bioavailable and selective antagonist of the prostaglandin e2 (pge2) receptor ep1 with ki value of 1.9 nm [1][2][3].prostaglandins contribute to the sensitization of peripheral and central nociceptive neurons during peripheral inflammation. prostaglandin e2 (pge2) is considered a dominant pronociceptive prostanoid. pge2 receptors are g protein-coupled receptors and classified into 4 general subtypes (ep1, ep2, ep3, and ep4) that are located unevenly in different tissues. ep1 receptors play a major role in processing of pain [1].in cystitis-related bladder pain mice, oral preadministration of ono-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent way. ono-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain. ono-8130 also blocked prostaglandin e2 caused prompt phosphorylation of erk in the l6 spinal cord [1]. in the guinea pig trachea (gpt), ono-8130 inhibited the initial contraction mediated by pge2. ono-8130 also eliminated the spontaneous tone [2].
storage
Store at +4°C
References
[1]. miki t, matsunami m, nakamura s, et al. ono-8130, a selective prostanoid ep1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. pain. 2011 jun;152(6):1373-81.
[2]. sfholm j, dahlén se, adner m. antagonising ep1 and ep2 receptors reveal that the tp receptor mediates a component of antigen-induced contraction of the guinea pig trachea. eur j pharmacol. 2013 oct 15;718(1-3):277-82.
ONO-8130 Preparation Products And Raw materials
Raw materials
Preparation Products
ONO-8130 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1990 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
