PARP
- CAS No.
- Chemical Name:
- PARP
- Synonyms
- PARP;PARP-1;BOVINE PARP;EC 2.4.2.30;PARP (BOVINE);PARP-1 (HUMAN);PARP-1 (BOVINE);BOVINE PARP ENZYME;POLY(ADP-RIBOSE) PROTEIN;POLY(ADP-RIBOSE) POLYMERASE
- CBNumber:
- CB4335241
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01324157
- MOL File:
- Mol file
Last updated:2023-04-23 13:52:06
| storage temp. | −70°C |
|---|---|
| form | buffered aqueous glycerol solution |
| NCI Dictionary of Cancer Terms | PARP; PARP-1; poly (ADP-ribose) polymerase-1 |
| FDA UNII | U25G2OFC53 |
SAFETY
Risk and Safety Statements
| Hazard Codes | B,T,N,Xn |
|---|---|
| Risk Statements | 20/22-24-37/38-41-51/53-43-36-20/21/22 |
| Safety Statements | 23-24/25-45-36/37/39-26-61-36/37 |
| WGK Germany | 1 |
PARP price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4500488 | Anti-PARP (Cleaved-Gly215) antibody produced in rabbit affinity isolated antibody | 100μg | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | P0996 | PARP-1 human recombinant, expressed in E. coli | 1000UNITS | $721 | 2024-03-01 | Buy | |
| Usbiological | 130886 | PARP1 | 100ug | $539 | 2021-12-16 | Buy | |
| Usbiological | 357912 | PARP1 | 48Tests | $588 | 2021-12-16 | Buy | |
| Usbiological | 488064 | PARP1 | 100ul | $499 | 2021-12-16 | Buy |
PARP Chemical Properties,Uses,Production
Uses
PARP-1 is a nuclear enzyme that synthesizes ADP-ribose polymers from NAD+, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. PARP1 has been used in a study to assess racial and tissue-specific cancer risk associated with polymorphism in the PARP1 gene. It has also been used in a study to investigate inhibitors of PARP-1 for potential cancer treatments.
General Description
Poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the inflammation response during atherosclerosis.
Biochem/physiol Actions
PARP-1 is inactivated by cleavage into a 24kDA and 89kDA fragment by activated caspase-3 or caspase-7. This results in the decreased ability to repair DNA damage and an increase in apoptosis.
PARP Preparation Products And Raw materials
Raw materials
Preparation Products
PARP Suppliers
Global( 26)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4698 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10036 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| United States Biological | 58 |
PARP
PARP-1 (BOVINE)
PARP-1 (BOVINE) AUTOMODIFIED
PARP-1 (HUMAN)
PARP (BOVINE)
POLY(ADP-RIBOSE) POLYMERASE
POLY(ADP-RIBOSE) POLYMERASE-1
POLY(ADP-RIBOSE) POLYMERASE-1 (AUTOMODIFIED)
POLY(ADP-RIBOSE) PROTEIN
POLY(ADP-RIBOSE) SYNTHETASE-1
POLY(ADP-RIBOSE) SYNTHETASE-1 (AUTOMODIFIED)
NAD+ ADP-RIBOSYLTRANSFERASE
BOVINE POLY(ADP-RIBOSE) POLYMERASE
BOVINE PARP
BOVINE PARP ENZYME
EC 2.4.2.30
Poly(ADP-ribose) Polymerase human
Poly(ADP-ribose) Polymerase Automodified bovine
Anti-Cyclin L2, C-Terminal antibody produced in rabbit
PARP-1
Poly(ADP-ribose) Synthetase
Anti-PARP (Cleaved-Gly215) antibody produced in rabbit
Human PARP1 Protein, His Tag