2-Amino-6-fluorobenzoic acid
- CAS No.
- 434-76-4
- Chemical Name:
- 2-Amino-6-fluorobenzoic acid
- Synonyms
- 6-FABA;BUTTPARK 44\01-59;TIMTEC-BB SBB006549;RARECHEM AL BO 0279;2-Amino-6-Fluorobenzoic;6-FLUOROANTHRANILIC ACID;2-amino-6-fluorobenzoate;6-FluoroanthranilicAcid>2-aMino-6-flourobenzoicacid;2-AMINO-6-FLUOROBENZOIC ACID
- CBNumber:
- CB4351052
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD00067781
- MOL File:
- 434-76-4.mol
- MSDS File:
- SDS
| Melting point | 167-169 °C (lit.) |
|---|---|
| Boiling point | 223.67°C (rough estimate) |
| Density | 1.3021 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | 4.01±0.10(Predicted) |
| form | Crystalline Powder |
| color | Yellow to brown |
| BRN | 3540926 |
| InChIKey | RWSFZKWMVWPDGZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 434-76-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Anthralic acid, 6-fluoro-(434-76-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
2-Amino-6-fluorobenzoic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 443026 | 2-Amino-6-fluorobenzoic acid 98% | 434-76-4 | 5g | $30.8 | 2023-01-07 | Buy |
| TCI Chemical | F0475 | 6-Fluoroanthranilic Acid >98.0%(GC)(T) | 434-76-4 | 1g | $29 | 2024-03-01 | Buy |
| TCI Chemical | F0475 | 6-Fluoroanthranilic Acid >98.0%(GC)(T) | 434-76-4 | 5g | $87 | 2024-03-01 | Buy |
| Alfa Aesar | A10919 | 2-Amino-6-fluorobenzoic acid, 98% | 434-76-4 | 1g | $34.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10919 | 2-Amino-6-fluorobenzoic acid, 98% | 434-76-4 | 5g | $114.65 | 2024-03-01 | Buy |
2-Amino-6-fluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.
Definition
ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid.
storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Synthesis
The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.
2-Amino-6-fluorobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1376 | 60 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
View Lastest Price from 2-Amino-6-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-05 | 2-Amino-6-fluorobenzoic acid
434-76-4
|
US $0.10 / KG | 0.1KG | 98% | 200TONS | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-02-22 | 2-Amino-6-fluorobenzoic acid
434-76-4
|
US $0.00 / KG | 1KG | 97.4% | 100 tons | Honest Joy Holdings Limited
|
|
 |
2019-07-06 | 2-Amino-6-fluorobenzoic acid
434-76-4
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 2-Amino-6-fluorobenzoic acid
434-76-4
- US $0.10 / KG
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Amino-6-fluorobenzoic acid
434-76-4
- US $0.00 / KG
- 97.4%
- Honest Joy Holdings Limited
-
- 2-Amino-6-fluorobenzoic acid
434-76-4
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
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