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CGP 20712 A

CGP 20712 A structure

CAS No.: 105737-62-0

Chemical Name:: CGP 20712 A

Synonyms: CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate

CBNumber:: CB4380786

Molecular Formula:: C24H29F3N4O8S

Molecular Weight:: 590.57

MDL Number:: MFCD06798358

MOL File:: 105737-62-0.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:13

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CGP 20712 A Properties

storage temp.	2-8°C
solubility	H₂O: 10 mg/mL
form	solid
color	white
FDA UNII	CNU8DA2K9J

SAFETY

Risk and Safety Statements

WGK Germany	3

CGP 20712 A price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C231	CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)	105737-62-0	10mg	$195.6	2024-03-01	Buy
Sigma-Aldrich	C231	CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)	105737-62-0	50mg	$1270	2023-01-07	Buy
Tocris	1024	CGP20712dihydrochloride ≥96%(HPLC)	105737-62-0	50	$936	2021-12-16	Buy
Tocris	1024	CGP20712dihydrochloride ≥96%(HPLC)	105737-62-0	10	$227	2021-12-16	Buy
Usbiological	254932	CGP 20712 dihydrochloride	105737-62-0	10mg	$480	2021-12-16	Buy

Product number	Packaging	Price	Buy
C231	10mg	$195.6	Buy
C231	50mg	$1270	Buy
1024	50	$936	Buy
1024	10	$227	Buy
254932	10mg	$480	Buy

CGP 20712 A Chemical Properties,Uses,Production

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A Preparation Products And Raw materials

Raw materials

Preparation Products

CGP 20712 A Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10648	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2990	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
Guangzhou Younan Technology Co., Ltd	020-82000279 18988968278	sales@ubiochem.com	China	4297	58
Nanjing Shizhou Biotechnology Co., Ltd	025-85563444 15850508050	rose.shi@synzest.com	China	269	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44808	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10002	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
HBCChem, Inc.	60
Sigma-Aldrich	80
Shanghai Rechem science Co., Ltd.	58
DC Chemicals	58
Guangzhou Younan Technology Co., Ltd	58
Nanjing Shizhou Biotechnology Co., Ltd	58
Energy Chemical	58
cjbscvictory	58

105737-62-0(CGP 20712 A )Related Search:

2-Methyl-4-trifluoromethylimidazole CGP 20712 A 1-(2-HYDROXY-ETHYLAMINO)-3-PHENOXY-PROPAN-2-OL 4-(Trifluoromethyl)-1H-imidazole 2-Phenyl-4-(trifluoromethyl)-1H-imidazole

2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE

1of2

CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE 1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd CGP207122HCl CGP-20712A methanesulfonate salt (±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE CGP 20712 DIHYDROCHLORIDE CGP 20712 mesylate 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate (+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate CGP-20712A methanesulfonate salt solid, >=98% (HPLC) 105737-62-0 C23H25F3N4O5CH4O3S C23H25F3N4O52HCl C24H27F3N4O7S Adrenoceptor