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ChemicalBook >> CAS DataBase List >>(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Structure
(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile structure
CAS No.
591239-68-8
Chemical Name:
(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile
Synonyms
ZINC05007751;NEK6 inibitor 8;NEK6 inhibitor 8;4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 1,2,5,6-tetrahydro-4-methyl-2,6-dioxo-5-[(5-phenyl-2-furanyl)methylene]-;(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile;HCT-15,NCI-H1299,PEO1,ovarian,Inhibitor,ZINC 05007751,inhibit,cells,ZINC05007751,NEK6,antiproliferative,ZINC-05007751
CBNumber:
CB43935639
Molecular Formula:
C18H12N2O3
Molecular Weight:
304.3
MDL Number:
MOL File:
591239-68-8.mol
Last updated:2024-11-19 20:33:22
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(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Properties

storage temp. 4°C, protect from light
solubility DMSO : 8.33 mg/mL (27.37 mM; ultrasonic and warming and heat to 60°C)
form Solid
color Brown to black

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals DC12465 NEK6inhibitor8 >98% 591239-68-8 10mg $400 2021-12-16 Buy
DC Chemicals DC12465 NEK6inhibitor8 >98% 591239-68-8 25mg $700 2021-12-16 Buy
Product number Packaging Price Buy
DC12465 10mg $400 Buy
DC12465 25mg $700 Buy

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Chemical Properties,Uses,Production

Biological Activity

ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1]. ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100 μM[1].ZINC05007751 induces perturbation of PEO1 cell cycle[1].ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 μM, with combination ZINC05007751 (44 μM) + Cisplatin (10 μM) exhibiting the greatest synergistic effect[1].

References

[1]. De Donato M, et al. Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6. Sci Rep. 2018;8(1):16047. Published 2018 Oct 30.

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 sales@chemhifuture.com China 3135 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 meilunui@163.com China 4727 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4512 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4601 55
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2991 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7269 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10270 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 58
Dalian Meilun Biotech Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58

View Lastest Price from (5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZINC05007751 pictures 2024-11-19 ZINC05007751
591239-68-8
 US $51.00-197.00 / mg 97.12% 10g TargetMol Chemicals Inc.
  • ZINC05007751 pictures
  • ZINC05007751
    591239-68-8
  • US $51.00-197.00 / mg
  • 97.12%
  • TargetMol Chemicals Inc.

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Spectrum

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile(591239-68-8)1HNMR

591239-68-8((5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile)Related Search:

ZINC13466751 6-hydroxy-3-methyl-5-(2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)propanamide 3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester Benzamide, 4-[2-[1,5-dihydro-1-(4-nitrophenyl)-5-oxo-3-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-
N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)acetamide ZINC03129319 6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol

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(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile NEK6 inibitor 8 ZINC05007751 3-Pyridinecarbonitrile, 1,2,5,6-tetrahydro-4-methyl-2,6-dioxo-5-[(5-phenyl-2-furanyl)methylene]- NEK6 inhibitor 8 HCT-15,NCI-H1299,PEO1,ovarian,Inhibitor,ZINC 05007751,inhibit,cells,ZINC05007751,NEK6,antiproliferative,ZINC-05007751 4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile 591239-68-8