ChemicalBook >> CAS DataBase List >>1A,1B-DIHOMO PROSTAGLANDIN E1

1A,1B-DIHOMO PROSTAGLANDIN E1

CAS No.
23452-98-4
Chemical Name:
1A,1B-DIHOMO PROSTAGLANDIN E1
Synonyms
1a,1b-dihomo PGE1;YMDDELUTDBQEMT-QZCLESEGSA-N;1A,1B-DIHOMO PROSTAGLANDIN E1;9-oxo-11α,15S-dihydroxy-1a,1b-dihomo-prost-13E-en-1-oic acid;9-OXO-11ALPHA,15S-DIHYDROXY-1A,1B-DIHOMO-PROST-13E-EN-1-OIC ACID;Cyclopentanenonanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, [1R-[1α,2β(1E,3S*),3α]]- (9CI)
CBNumber:
CB4404411
Molecular Formula:
C22H38O5
Molecular Weight:
382.53
MDL Number:
MFCD00797640
MOL File:
Mol file
Last updated:2023-06-08 09:03:09

1A,1B-DIHOMO PROSTAGLANDIN E1 Properties

Boiling point 550.1±50.0 °C(Predicted)
Density 1.104±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: >100 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1.6 mg/ml
pka 4.78±0.10(Predicted)

1A,1B-DIHOMO PROSTAGLANDIN E1 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13050 1a,1b-dihomo Prostaglandin E1 ≥98% 23452-98-4 1mg $64 2024-03-01 Buy
Cayman Chemical 13050 1a,1b-dihomo Prostaglandin E1 ≥98% 23452-98-4 5mg $280 2024-03-01 Buy
Cayman Chemical 13050 1a,1b-dihomo Prostaglandin E1 ≥98% 23452-98-4 10mg $497 2024-03-01 Buy
American Custom Chemicals Corporation LIP0000809 1A,1B-DIHOMO PROSTAGLANDIN E1 95.00% 23452-98-4 5MG $497.3 2021-12-16 Buy
AK Scientific 3070EL 9-[(2R)-3-Hydroxy-2-[(E)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]nonanoicacid 23452-98-4 10mg $650 2021-12-16 Buy
Product number Packaging Price Buy
13050 1mg $64 Buy
13050 5mg $280 Buy
13050 10mg $497 Buy
LIP0000809 5MG $497.3 Buy
3070EL 10mg $650 Buy

1A,1B-DIHOMO PROSTAGLANDIN E1 Chemical Properties,Uses,Production

Description

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.3 In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.4

Definition

ChEBI: 1a,1b-dihomo-PGE1 is a prostanoid.

References

1. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases J. Urol. 145(2),287-293(1991).
2. Hoshi, K. Approved indications of lipo-PGE1 in Japan Adv. Drug Deliv. Rev. 20(2-3),171-176(1996).
3. Samel, N., and Maxey, K.M. Personal Communication ,(2003).
4. Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins Biochim. Biophys. Acta 187(3),285-292(1969).

1A,1B-DIHOMO PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18018 56
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 56068 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 hanfangpharma@126.com China 30968 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28118 58
9-OXO-11ALPHA,15S-DIHYDROXY-1A,1B-DIHOMO-PROST-13E-EN-1-OIC ACID 1A,1B-DIHOMO PROSTAGLANDIN E1 YMDDELUTDBQEMT-QZCLESEGSA-N 1a,1b-dihomo PGE1 9-oxo-11α,15S-dihydroxy-1a,1b-dihomo-prost-13E-en-1-oic acid Cyclopentanenonanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, [1R-[1α,2β(1E,3S*),3α]]- (9CI) 23452-98-4