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AMCINONIDE

AMCINONIDE structure

CAS No.: 51022-69-6

Chemical Name:: AMCINONIDE

Synonyms: Amicla;Visderm;cl-34699;Amciderm;Ansinede;Penticort;Amcinonid;cyclocort;Amcinopol;AMCINONIDE

CBNumber:: CB4419202

Molecular Formula:: C28H35FO7

Molecular Weight:: 502.57

MDL Number:: MFCD00213379

MOL File:: 51022-69-6.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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AMCINONIDE Properties

Melting point	>216°C (dec.)
Boiling point	635.9°C (rough estimate)
Density	1.33±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	1.5860 (estimate)
storage temp.	-20°C Freezer
solubility	Acetonitrile (Slightly), Dichlomethane (Slightly), Dioxane (Slightly), Methanol
pka	13.09±0.70(Predicted)
form	Solid
color	White to Off-White
FDA UNII	423W026MA9
ATC code	D07AC11

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361-H373
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P260-P314-P501
WGK Germany	2
RTECS	TU3682500
HS Code	2937220000

AMCINONIDE price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1019202	Amcinonide United States Pharmacopeia (USP) Reference Standard	51022-69-6	200mg	$381	2024-03-01	Buy
Cayman Chemical	23903	Amcinonide ≥98%	51022-69-6	50mg	$33	2024-03-01	Buy
Cayman Chemical	23903	Amcinonide ≥98%	51022-69-6	100mg	$60	2024-03-01	Buy
Cayman Chemical	23903	Amcinonide ≥98%	51022-69-6	250mg	$116	2024-03-01	Buy
Cayman Chemical	23903	Amcinonide ≥98%	51022-69-6	500mg	$213	2024-03-01	Buy

Product number	Packaging	Price	Buy
1019202	200mg	$381	Buy
23903	50mg	$33	Buy
23903	100mg	$60	Buy
23903	250mg	$116	Buy
23903	500mg	$213	Buy

AMCINONIDE Chemical Properties,Uses,Production

Originator

Cyclocort,Lederle,US,1979

Uses

antiinflammatory

Uses

Glucocorticoid.

Definition

ChEBI: Amcinonide is a corticosteroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 20-oxo steroid, an acetate ester, a spiroketal and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane.

Manufacturing Process

An 11.1 g (24.1 mmol) portion of the compound 16α,17α- cyclopentylidenedioxy-9α-fluoro-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione is placed in a 250 ml round-bottom flask. A 100 ml portion of pyridine is added and the mixture is stirred to a complete solution. A 5.5 ml (54.6 mmol) portion of acetic anhydride is added dropwise and the mixture is stirred for 2% hours. An 11 ml portion of methanol is added and the mixture is stirred an additional hour. This mixture is concentrated under reduced pressure to about 10 to 15 ml and then poured slowly into a mixture of ice, water and dilute hydrochloric acid. This mixture is stirred and the solid which forms is collected by filtration, washed with water to a neutral pH and air dried yielding 11.5 g. This solid is taken up in hot acetone, treated with activated charcoal and filtered while hot through diatomaceous earth. The filtrate is concentrated on a steam bath while adding n-hexane to the point of incipient crystallization. This mixture is allowed to cool to room temperature. The solid which forms is collected by filtration, washed with acetone-n-hexane (1:14) and air dried yielding 7.0 g of the desired product.

brand name

Cyclocort (Astellas.

Therapeutic Function

Topical corticosteroid, Antiinflammatory

General Description

Amcinonide, 21-(acetyloxy)-16α,17-[cyclopentylidenebis(oxy)]-9-fluoro-11β-hydroxypregna-1,4-diene-3,20-dione (Cyclocort).

AMCINONIDE Preparation Products And Raw materials

Raw materials

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Acetic anhydride

Preparation Products

AMCINONIDE Suppliers

Global( 122)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49978	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	sales@senfeida.com	China	23046	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Wuhan Quanjinci New Material Co.,Ltd.	+86-15271838296; +8615271838296	kyra@quanjinci.com	China	1512	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Nanjing Doge Biomedical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Wuhan Quanjinci New Material Co.,Ltd.	58

View Lastest Price from AMCINONIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Amcinonide 51022-69-6	US $35.00-72.00 / mg		99.62%	10g	TargetMol Chemicals Inc.
	2024-11-19	Amcinonide 51022-69-6	US $35.00-72.00 / mg		99.62%	10g	TargetMol Chemicals Inc.

Amcinonide
51022-69-6
US $35.00-72.00 / mg
99.62%
TargetMol Chemicals Inc.

Amcinonide
51022-69-6
US $35.00-72.00 / mg
99.62%
TargetMol Chemicals Inc.

AMCINONIDE Spectrum

AMCINONIDE(51022-69-6)¹HNMR

51022-69-6(AMCINONIDE)Related Search:

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AMCINONIDE Triamcinolone Isoflupredone Acetate 1,1-DIMETHOXYCYCLOPENTANE 1,3-DIMETHOXYACETONE

CYCLOPENTANONE ETHYLENE KETAL 6(R),7-ISOPROPYLIDENE-HEPTANOL 2,2-Dimethyl-4-hexyl-1,3-dioxolane

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AMCINONIDE (11-beta,16-alpha)-fluoro-11-hydroxy 20-dione,21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-pregna-4-diene-3 cl-34699 cyclocort Amciderm Amcinonid Penticort Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-, (11β,16α)- Spiro[cyclopentane-1,8'-[2H]naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole], pregna-1,4-diene-3,20-dione deriv. Visderm Amcinopol Amicla Amcinonide (200 mg)H0D3460.995mg/mg(ai) Amcinonide (200 mg) Amcinonide Solution, 100ppm (11β,16α)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione (11alpha,16alpha)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-2',4',6a',6b',7',8',8a',8b',11a',12',12a',12b'-dodecahydro-1'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate Amcinonide (1019202) Ann's sinai Glucocorticoid Receptor,CL34699,CL 34699,inhibit,Amcinonide,Inhibitor Ansinede 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-Fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-1',2',4',6a',6b',7',8',8a',11a',12',12a',12b'-dodecahydro-8b'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate 51022-69-6 C28H35FO7 Analytical Standards AM to AQ Analytical Chromatography Product Catalog Alphabetic RELAFEN Intermediates & Fine Chemicals Pharmaceuticals Steroids