1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine

1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine structure

CAS No.: 433966-92-8

Chemical Name:: 1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine

Synonyms: AE 51310;1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine;Piperidine, 1-[(2,5-dichloro-4-methoxyphenyl)sulfonyl]-3-methyl-

CBNumber:: CB44224974

Molecular Formula:: C13H17Cl2NO3S

Molecular Weight:: 338.25

MDL Number:

MOL File:: 433966-92-8.mol

Last updated:2023-04-23 13:52:06

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1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine Properties

Boiling point	452.3±55.0 °C(Predicted)
Density	1.338±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (>25 mg/ml)
form	solid
pka	-5.74±0.40(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine Chemical Properties,Uses,Production

Description

AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind Ga11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.2

References

Jones et al. (2013), Small-molecule antagonists of melanopsin-mediated phototransduction; Nat. Chem. Biol. 9 630 Wang et al. (2020), Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression; Mol. Cancer Res. 18 1028

1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Focus Biomolecules	--	sales@focusbiomolecules.com	United States	1284	58
OTAVA chemicals	--	north.america@otavachemicals.com	Ukraine	6495	72

Supplier	Advantage
Focus Biomolecules	58
OTAVA chemicals	72

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1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine AE 51310 Piperidine, 1-[(2,5-dichloro-4-methoxyphenyl)sulfonyl]-3-methyl- 433966-92-8