6-HYDROXYMELATONIN
- CAS No.
- 2208-41-5
- Chemical Name:
- 6-HYDROXYMELATONIN
- Synonyms
- Sutan (Butylate);6-HYDROXYMELATONIN;6-Hydroxymelatonine;MELATONIN, 6-HYDROXY;Melatonin 6-Hydroxy Impurity;6Hydroxymelatonin,6 Hydroxymelatonin;N-ACETYL-6-HYDROXY-5-METHOXYTRYPTAMINE;6-HYDROXY-N-ACETYL-5-METHOXYTRYPTAMINE;Melatonin Impurity 3 (6-Hydroxy Melatonin);3-[N-ACETYLAMINOETHYL]-6-HYDROXY-5-METHOXYINDOLE
- CBNumber:
- CB4436858
- Molecular Formula:
- C13H16N2O3
- Molecular Weight:
- 248.28
- MDL Number:
- MFCD00037971
- MOL File:
- 2208-41-5.mol
| Melting point | 172-175°C |
|---|---|
| Boiling point | 564.7±50.0 °C(Predicted) |
| Density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | alcohol: soluble |
| form | Solid |
| pka | 10.12±0.40(Predicted) |
| color | White to Beige |
| InChIKey | OMYMRCXOJJZYKE-UHFFFAOYSA-N |
| FDA UNII | TV437T5077 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H351 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-40-51/53-20 | |||||||||
| Safety Statements | 36/37-60 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AC3607000 | |||||||||
| NFPA 704 |
|
6-HYDROXYMELATONIN price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H0627 | 6-Hydroxymelatonin | 2208-41-5 | 50mg | $782 | 2024-03-01 | Buy |
| Cayman Chemical | 21857 | 6-hydroxy Melatonin ≥95% | 2208-41-5 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 21857 | 6-hydroxy Melatonin ≥95% | 2208-41-5 | 5mg | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 21857 | 6-hydroxy Melatonin ≥95% | 2208-41-5 | 10mg | $380 | 2024-03-01 | Buy |
| TRC | H944625 | 6-HydroxyMelatonin | 2208-41-5 | 5mg | $165 | 2021-12-16 | Buy |
6-HYDROXYMELATONIN Chemical Properties,Uses,Production
Description
6-hydroxy Melatonin is an active metabolite of melatonin . It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 μM). 6-hydroxy Melatonin (10 and 100 μM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis. It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.
Chemical Properties
Off-White to Pale Beige Solid
Uses
A metabolite of Melatonin (M215000).
Uses
A metabolite of Melatonin (S689050).
Uses
A major human metabolite of Melatonin
Uses
6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.
Definition
ChEBI: A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6.
General Description
6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.
Biochem/physiol Actions
6-Hydroxymelatonin (6-OHM) is an antioxidant with a free radical scavenging role. Like melatonin, it reduces the impact of UVB-induced oxidative stress in melanocytes. It also aids protection during iron (Fe2+)-induced neurotoxicity. 6-OHM effectively reduces lipid peroxidation and superoxide anion production induced by potassium cyanide (KCN).
6-HYDROXYMELATONIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |