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4'-Methylthioacetophenone

4'-Methylthioacetophenone structure

CAS No.: 1778-09-2

Chemical Name:: 4'-Methylthioacetophenone

Synonyms: Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE;Etoricoxib Impurity 61;4-THIOMETHYLACETOPHENONE;4'-Methylthioacetophenone

CBNumber:: CB4454274

Molecular Formula:: C9H10OS

Molecular Weight:: 166.24

MDL Number:: MFCD00039835

MOL File:: 1778-09-2.mol

MSDS File:: SDS

Last updated:2024-11-13 11:39:19

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4'-Methylthioacetophenone Properties

Melting point	80-82 °C(lit.)
Boiling point	135 °C
Density	1.1369 (rough estimate)
refractive index	1.5600 (estimate)
Flash point	135°C/1mm
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Solid
color	White to Off-White
BRN	1860517
InChI	InChI=1S/C9H10OS/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
InChIKey	JECUZQLBQKNEMW-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(SC)C=C1)C
CAS DataBase Reference	1778-09-2(CAS DataBase Reference)
FDA UNII	FN9JM37X2P
NIST Chemistry Reference	4-CH3S-C6H4-COCH3(1778-09-2)
EPA Substance Registry System	4'-(Methylmercapto)acetophenone (1778-09-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29309099

NFPA 704

	1
2		0

4'-Methylthioacetophenone price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	396583	4′-(Methylthio)acetophenone 97%	1778-09-2	1g	$28.9	2024-03-01	Buy
TCI Chemical	M1672	4'-(Methylthio)acetophenone >98.0%(GC)	1778-09-2	5g	$71	2024-03-01	Buy
TCI Chemical	M1672	4'-(Methylthio)acetophenone >98.0%(GC)	1778-09-2	25g	$207	2024-03-01	Buy
Alfa Aesar	L18074	4'-(Methylthio)acetophenone, 99%	1778-09-2	5g	$88.65	2024-03-01	Buy
Alfa Aesar	L18074	4'-(Methylthio)acetophenone, 99%	1778-09-2	25g	$323.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
396583	1g	$28.9	Buy
M1672	5g	$71	Buy
M1672	25g	$207	Buy
L18074	5g	$88.65	Buy
L18074	25g	$323.65	Buy

4'-Methylthioacetophenone Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powde

Uses

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048

General Description

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

4'-Methylthioacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-METHYLTHIOPHENYL)PYRIDINE JR-13707, 3-(4-(Methylthio)phenyl)-1H-pyrazol-5-amine, 97% Ethyl 3-[4-(Methylsulfanyl)phenyl]-3-oxopropanoate

4'-Methylthioacetophenone Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Liteng Biotechnology Co. , Ltd.	+86-18663721413 +86-15552573001	info@litengpharm.com	China	595	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Shandong Liteng Biotechnology Co. , Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 4'-Methylthioacetophenone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	4"-Methylthioacetophenone 1778-09-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	4'-Methylthioacetophenone 1778-09-2	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

4"-Methylthioacetophenone
1778-09-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4'-Methylthioacetophenone
1778-09-2
US $7.00 / KG
99%
Career Henan Chemical Co

4'-Methylthioacetophenone Spectrum

4'-Methylthioacetophenone(1778-09-2)¹HNMR 4'-Methylthioacetophenone(1778-09-2)FT-IR 4'-Methylthioacetophenone(1778-09-2)IR

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4-(Methyl thio) Ethanone,1-[4-(methylthio) 4-(METHYLTHIO)ACETOPHENONE 99% 4-THIOMETHYLACETOPHENONE Dodecane-1-sulfonyl chloride 1-Acetyl-4-(methylthio)benzene Methyl 4-acetylphenyl sulfide Methyl(4-acetylphenyl) sulfide p-Acetylthioanisole 4'-(Methylthio)acetophenone,97% 4'-Methylthioacetoph 1-[4-(Methylsulfanyl)phenyl]ethan-1-one 1-[4-(Methylsulphanyl)phenyl]ethan-1-one, 4-Acetylthioanisole 1-[4-(METHYLSULFANYL)PHENYL]ETHANONE 1-[4-(methylthio)phenyl]ethan-1-one 1-[4-(METHYLTHIO)PHENYL]ETHANONE 4-METHYLMERCAPTOACETOPHENONE 4'-(METHYLTHIO)ACETOPHENONE P-(METHYLTHIO)ACETOPHENONE 4-(ACETYL)THIOANISOLE 4'-(Methylthio)acetophenone> Etoricoxib Impurity 61 Ethanone, 1-[4-(methylthio)phenyl]- 4-(METHYLTHIO)ACETOPHENONE 4 ′- (meththyl) phenylacetone Glycerol Impurity 24 4'-Methylthioacetophenone 1778-09-2 C9H10OS CH3SC6H4COCH3 Organic Building Blocks Sulfur Compounds Sulfides/Disulfides Building Blocks Osteoarthritis and Rheumatoid Arthritis Organic Building Blocks Sulfides/Disulfides Sulfur Compounds Aromatic Acetophenones & Derivatives (substituted)