ChemicalBook >> CAS DataBase List >>4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide structure

CAS No.: 940290-58-4

Chemical Name:: 4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide

Synonyms: 4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide

CBNumber:: CB44751568

Molecular Formula:: C17H13N3O2

Molecular Weight:: 291.30402

MDL Number:

MOL File:: 940290-58-4.mol

Last updated:2024-07-02 08:55:09

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4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide Properties

storage temp.	Store at -20°C
form	Solid
color	White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H400
Precautionary statements	P264-P270-P301+P312-P330-P501-P273-P391-P501

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide Chemical Properties,Uses,Production

Biological Activity

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1]. UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1]. UK122 (10-100 μM; 48 h) has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].

References

[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29778	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide 940290-58-4