ChemicalBook >> CAS DataBase List >>RGX-104 free Acid
RGX-104 free Acid
- CAS No.
- 610318-54-2
- Chemical Name:
- RGX-104 free Acid
- Synonyms
- SB742881;RGX-104 free Acid;RGX-104 (free form);RGX-104, 10 mM in DMSO;Abequolixron (RGX-104);RGX-104freeAcid/SB742881;610318-54-2 (FREE FORM) 610318-03-1 (HCL);RGX 104,inhibit,LXR,RGX-104,Liver X receptor,RGX104,Inhibitor;(R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid;Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-
- CBNumber:
- CB44808622
- Molecular Formula:
- C34H33ClF3NO3
- Molecular Weight:
- 596.08
- MDL Number:
- MFCD31726291
- MOL File:
- 610318-54-2.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 677.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO:100.0(Max Conc. mg/mL);167.76(Max Conc. mM) |
| form | Solid |
| pka | 4.19±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | Q26B92650V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
RGX-104 free Acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0080747 | RGX-104freeAcid 99.97% | 610318-54-2 | 2mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0080747 | RGX-104freeAcid 99.97% | 610318-54-2 | 5mg | $190 | 2021-12-16 | Buy |
| ChemScene | CS-0080747 | RGX-104freeAcid 99.97% | 610318-54-2 | 10mg | $290 | 2021-12-16 | Buy |
| ChemScene | CS-0080747 | RGX-104freeAcid 99.97% | 610318-54-2 | 25mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-0080747 | RGX-104freeAcid 99.97% | 610318-54-2 | 50mg | $850 | 2021-12-16 | Buy |
RGX-104 free Acid Chemical Properties,Uses,Production
Uses
RGX-104 is combination of a liver X receptor β agonist and GITR modulator for treatment of cancer.Liver X receptor beta agonist.
in vivo
Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1].
| Animal Model: | NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1]. |
| Dosage: | 100 mg/kg. |
| Administration: | Oral administration daily for about 60 days. |
| Result: | Robustly suppressed tumor growth and progression. |
RGX-104 free Acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 43)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38642 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2992 | 58 |
RGX-104 free Acid
610318-54-2 (FREE FORM) 610318-03-1 (HCL)
RGX-104 (free form)
SB742881
Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-
RGX-104freeAcid/SB742881
Abequolixron (RGX-104)
(R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid
RGX 104,inhibit,LXR,RGX-104,Liver X receptor,RGX104,Inhibitor
RGX-104, 10 mM in DMSO
610318-54-2
C34H33ClF3NO3