FEN1-IN-1
- CAS No.
- 824983-91-7
- Chemical Name:
- FEN1-IN-1
- Synonyms
- LNT 1;FEN1-IN-1;FEN1 inhibitor 1;EN1 Inhibitor C1;LNT 1 (FEN1-IN-1);FEN1 IN 1,FEN-1-IN-1,inhibit,Inhibitor,FEN1IN1;1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-;1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
- CBNumber:
- CB44844767
- Molecular Formula:
- C15H12N2O5S
- Molecular Weight:
- 332.33
- MDL Number:
- MOL File:
- 824983-91-7.mol
| Boiling point | 548.9±52.0 °C(Predicted) |
|---|---|
| Density | 1.583±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO (15 mg/ml) |
| form | solid |
| pka | 7.91±0.20(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
FEN1-IN-1 Chemical Properties,Uses,Production
Description
LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4
storage
Store at -20°C
References
Tumey et al. (2005), The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors; Med. Chem. Lett., 15 277 Exell et al. (2016), Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site; Chem. Biol., 12 815 Ward et al. (2017), Small molecules inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes; PLoS One, 12 e0179278 Guo et al. (2020), FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination; Natl. Acad. Sci USA 117 19415
FEN1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
FEN1-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4575 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 568 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 10789 | 58 |
