ChemicalBook >> CAS DataBase List >>BAY-218
BAY-218
- CAS No.
- 2162982-11-6
- Chemical Name:
- BAY-218
- Synonyms
- CPD3504;BAY-218;BAY-2335218;AHR antagonist 1;BAY-218, 10 mM in DMSO;BAY-218(AHR antagonist 1);BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218;6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(1S)-2-hydroxy-1-methyl-ethyl]-3-oxo-pyridazine-4-carboxamide;(S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide;6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide
- CBNumber:
- CB44908494
- Molecular Formula:
- C20H17ClFN3O3
- Molecular Weight:
- 401.82
- MDL Number:
- MOL File:
- 2162982-11-6.mol
Last updated:2025-04-17 18:22:24
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BAY-218 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0040922 | AHRantagonist1 99.07% | 2162982-11-6 | 5mg | $100 | 2021-12-16 | Buy |
ChemScene | CS-0040922 | AHRantagonist1 99.07% | 2162982-11-6 | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0040922 | AHRantagonist1 99.07% | 2162982-11-6 | 25mg | $290 | 2021-12-16 | Buy |
ChemScene | CS-0040922 | AHRantagonist1 99.07% | 2162982-11-6 | 50mg | $490 | 2021-12-16 | Buy |
ChemScene | CS-0040922 | AHRantagonist1 99.07% | 2162982-11-6 | 100mg | $850 | 2021-12-16 | Buy |
BAY-218 Chemical Properties,Uses,Production
Uses
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses[1].
in vivo
BAY-218 (example 23) (p.o; 30 mg/kg; bid) has good anti-tumor effect combinated with aPD-L1[1].
Animal Model: | Balb/c mice (subcutaneously CT26 cells)[1] |
Dosage: | 30 mg/kg |
Administration: | p.o, bid |
Result: | Significantly decreased tumors size combinated with aPD-L1. |
References
[1] Norbert Schmees, et al. 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides. WO2017202816A1.
BAY-218 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-218 Suppliers
Global( 69)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218
BAY-218
CPD3504
BAY-2335218
AHR antagonist 1
4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-
6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide
(S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide
BAY-218(AHR antagonist 1)
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6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(1S)-2-hydroxy-1-methyl-ethyl]-3-oxo-pyridazine-4-carboxamide
BAY-218, 10 mM in DMSO
2162982-11-6