MICROCYSTIN LA
- CAS No.
- 96180-79-9
- Chemical Name:
- MICROCYSTIN LA
- Synonyms
- toxinbe4;cyanoginosin-la;Microcystin-leucine-alanine;DIAQQISRBBDJIM-DRSCAGMXSA-N;Toxin be 4 (microcystis aeruginosa);Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
- CBNumber:
- CB4503842
- Molecular Formula:
- C46H67N7O12
- Molecular Weight:
- 910.064
- MDL Number:
- MFCD32693968
- MOL File:
- 96180-79-9.mol
- MSDS File:
- SDS
| Boiling point | 1237.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | methanol: 2 mg/mL |
| pka | 3.03±0.70(Predicted) |
| form | Whitish film adhered to inside of the vial. |
| color | Colorless to off-white |
| EWG's Food Scores | 1 |
| FDA UNII | 3E7C54U3SY |
| EPA Substance Registry System | Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-.beta.-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (96180-79-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H319-H300-H315-H310-H335-H330-H317 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-36/37/38-43 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GT2805000 | |||||||||
| NFPA 704 |
|
MICROCYSTIN LA price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10007187 | Microcystin-LA ≥95% | 96180-79-9 | 25μg | $189 | 2024-03-01 | Buy |
| Cayman Chemical | 10007187 | Microcystin-LA ≥95% | 96180-79-9 | 100μg | $378 | 2024-03-01 | Buy |
| Cayman Chemical | 10007187 | Microcystin-LA ≥95% | 96180-79-9 | 1mg | $3017 | 2024-03-01 | Buy |
| Cayman Chemical | 10007187 | Microcystin-LA ≥95% | 96180-79-9 | 500μg | $1085 | 2021-12-16 | Buy |
| ChemScene | CS-0021541 | Microcystin-LA | 96180-79-9 | 100ug | $650 | 2021-12-16 | Buy |
MICROCYSTIN LA Chemical Properties,Uses,Production
Description
Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.
Uses
Microcystin LA from algae has been used as a standard for liquid chromatography/mass spectrometry (LCMS) for toxin analysis.
Definition
ChEBI: Microcystin la is a peptide.
General Description
Microcystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin. Microcystin has four congeners namely, -LR, -LA, -YR and -RR.
Biochem/physiol Actions
Microcystin LA inhibits protein phosphatase type 2A and protein phosphatase type 3 more potently than protein phosphatase type 1 (order of potency PP2A > PP3 > PP1). Induces neutrophil-activating chemokines and extracellular reactive oxygen species, possible mechanisms of its hepatotoxic effects.
MICROCYSTIN LA Preparation Products And Raw materials
Raw materials
Preparation Products
MICROCYSTIN LA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25003 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | shanpel@anpel.com.cn | China | 9611 | 58 |
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 18561885118 | market@tlwb.com.cn | China | 3944 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10002 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |