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DL-Selenomethionine

CAS No.
1464-42-2
Chemical Name:
DL-Selenomethionine
Synonyms
Selenomethionine;Selenium methionine;seleniummethionine;Seleno-DL-methionine;C05335;DL-Se-Met;methionine,seleno;Methionine, seleno;DL-SELENOMETHIONINE;SELENOMETHIONINE 98+%
CBNumber:
CB4505790
Molecular Formula:
C5H11NO2Se
Molecular Weight:
196.11
MDL Number:
MFCD00063089
MOL File:
1464-42-2.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:52

DL-Selenomethionine Properties

Melting point 267-269 °C
Boiling point 320.8±37.0 °C(Predicted)
storage temp. -20°C
solubility almost transparency in 1mol/L HCl
pka 2.26±0.10(Predicted)
form solid
color White to Almost white
Water Solubility soluble
Merck 14,8441
BRN 1758204
EWG's Food Scores 1
FDA UNII J9V40V4PKZ
NIST Chemistry Reference Butanoic acid, 2-amino-4-(methylseleno)-(1464-42-2)
EPA Substance Registry System Butanoic acid, 2-amino-4-(methylseleno)- (1464-42-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H331-H373-H410
Precautionary statements  P260-P264-P273-P301+P310-P304+P340+P311-P314
Hazard Codes  T,N
Risk Statements  23/25-33-50/53
Safety Statements  20/21-28-45-60-61
RIDADR  UN 3283
WGK Germany  3
RTECS  ES7110000
HazardClass  6.1
PackingGroup  III
HS Code  2931909000
Hazardous Substances Data 1464-42-2(Hazardous Substances Data)
NFPA 704
0
3 0

DL-Selenomethionine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S3875 Seleno-DL-methionine ≥99% (TLC) 1464-42-2 1g $463 2024-03-01 Buy
Sigma-Aldrich PHR2613 Selenomethionine 1464-42-2 200MG $200 2024-03-01 Buy
Sigma-Aldrich S3875 Seleno-DL-methionine ≥99% (TLC) 1464-42-2 25mg $58.2 2023-06-20 Buy
TCI Chemical S0462 DL-Selenomethionine >98.0%(HPLC)(T) 1464-42-2 1g $255 2024-03-01 Buy
Sigma-Aldrich S3875 Seleno-DL-methionine ≥99% (TLC) 1464-42-2 100mg $121 2024-03-01 Buy
Product number Packaging Price Buy
S3875 1g $463 Buy
PHR2613 200MG $200 Buy
S3875 25mg $58.2 Buy
S0462 1g $255 Buy
S3875 100mg $121 Buy

DL-Selenomethionine Chemical Properties,Uses,Production

Description

Preparation of 4'-Bromoacetanilide from Acetanilide.
Principle: Aromatic compounds can be conveniently brominated by the use of brominating agent, which is normally a solution of bromine in acetic acid. Bromination of activated aromatic compounds usually give 2, 4, 6-tribromo derivatives while moderately activating group like anilide give preferably the para bromo product.
Reaction:
Preparation of 4'-Bromoacetanilide from Acetanilide
Procedure: Dissolve 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 2.5 ml bromine solution in acetic acid (25% w/v). Shake the mixture for 1 h. After 1 h, pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as a solvent).

Description

Selenomethionine is the major form of selenium in plant foods. Selenomethionine is identical to methionine, except that selenium replaces the sulfur atom. The selenium consumed as selenocysteine is broken down to form alanine and hydrogen selenide (H2Se). The breakdown pathway of selenomethion- ine is not clear. Although selenium does not occur to a great extent as selenite in foods, selenite is readily used as a source of the element by humans and animals. Selenium also occurs as selenate in foods such as beet leaves, garlic, and cabbage.
DL-Selenomethionine
DL-Selenomethionine is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues. Free selenium is incorporated into selenocysteine, an amino acid found in more than thirty selenoproteins including the glutathione peroxidases (GPx) enzymes, thioredoxin reductase (TR) and the iodothyronine deiodinase enzymes.

Uses

contrast agent

Uses

Selenium as selenite, DL-selenomethionine, and DL-selenocystine was equally effective in preventing liver necrosis, but factor 3 selenium was three times more effective than these forms (Burk, 1976; Schwarz and Foltz, 1958).

Definition

ChEBI: Selenomethionine is a selenoamino acid that is the selenium analogue of methionine. It has a role as a plant metabolite. It is a member of selenomethionines and a selenoamino acid.

Biological Functions

Most selenium in animal tissues is present as selenomethionine or selenocysteine. Selenomethionine, which cannot be synthesized by humans and is initially synthesized in plants, is incorporated randomly in place of methionine in a variety of proteins obtained from plant and animal sources. Selenium is present in varying amounts in these proteins, which are called selenium-containing proteins.
Selenomethionine is not known to have a physiological function separate from that of methionine.
Selenocysteine is present in animal selenoproteins that have been characterized (see below) and is the form of selenium that accounts for the biological activity of the element. In contrast to selenomethionine, there is no evidence that selenocysteine substitutes for cysteine in humans.

Biological Activity

Most dietary selenium is highly bioavailable. Selenomethionine, which is estimated to account for at least half of the dietary selenium, is absorbed by the same mechanism as methionine, and its selenium is made available for selenoprotein synthesis when it is catabolized via the transsulfuration pathway (Esaki et al., 1982). The bioavailability of selenium in the form of selenomethionine is greater than 90 percent (Thomson and Robinson, 1986). The selenium in selenocysteine, another significant dietary form, is also highly bioavailable (Swanson et al., 1991). There appear to be some minor dietary forms of selenium (especially present in fish) that have relatively low bioavailability, but these forms have not been identified (Cantor and Tarino, 1982). Selenate and selenite, two inorganic forms of selenium, have roughly equivalent bioavailability which generally exceeds 50 percent (Thomson and Robinson, 1986). Although they are not major dietary constituents, these inorganic forms are commonly used as selenium supplements.

Metabolism

Selenomethionine, derived mainly from plants, enters the methionine pool in the body and shares the fate of methionine until catabolized by the transsulfuration pathway. The resulting free selenocysteine is further broken down with liberation of a reduced form of the element, which is designated selenide (Esaki et al., 1982). Ingested selenite, selenate, and selenocysteine are all apparently metabolized directly to selenide. This selenide may be associated with a protein that serves as a chaperone (Lacourciere and Stadtman, 1998). The selenide can be metabolized to selenophosphate, the precursor of selenocysteine in selenoproteins (Ehrenreich et al., 1992) and of selenium in transfer RNA (Veres et al., 1992), or it can be converted to excretory metabolites (Mozier et al., 1988), some of which have been characterized as methylated forms.

Purification Methods

It crystallises in hexagonal plates from MeOH and H2O. [Klosterman & Painter J Am Chem Soc 69 2009 1949.] The L-isomer [3211-76-5] is purified by dissolving it in H2O, adjusting the pH to 5.5 with aqueous NH3, evaporating to near-dryness, and the residue is washed several times with absolute EtOH till a solid is formed and then recrystallise from Me2CO. It has m 266-268o(dec) [also 275o(dec)], and [] D +18.1o(c 1, N HCl). [Pande et al. J Org Chem 35 1440 1970, Beilstein 4 IV 3216.]

DL-Selenomethionine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 194)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd
+8615531157085 abby@weibangbio.com China 8807 58
Shaanxi Dideu Medichem Co. Ltd
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Hebei Mojin Biotechnology Co., Ltd
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Henan Fengda Chemical Co., Ltd
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Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co
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Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

View Lastest Price from DL-Selenomethionine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Selenomethionine pictures 2024-11-19 Selenomethionine
1464-42-2
US $86.00-47.00 / mg ≥95% 10g TargetMol Chemicals Inc.
Selenomethionine pictures 2024-10-30 Selenomethionine
1464-42-2
US $1.00-1.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
DL-Selenomethionine pictures 2024-09-25 DL-Selenomethionine
1464-42-2
US $0.00-0.00 / mg 25mg 99% 60kg Wuhan Senwayer Century Chemical Co.,Ltd
  • Selenomethionine pictures
  • Selenomethionine
    1464-42-2
  • US $1.00-1.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd

DL-Selenomethionine Spectrum

2-amino-4-(methylselenyl)-butyricaci 2-amino-4-(methylselenyl)butyricacid Butyric acid, 2-amino-4-(methylselenyl)- Methionine, seleno methionine,seleno selenomethionine(van) SELENOMETHIONINE (100 MG) DL-SELENOMETHIONINE SELENOMETHIONINE 98+% Butanoic acid, 2-amino-4-(methylseleno)- 2-amino-4-methylselanyl-butanoic acid 2-Amino-4-(methylseleno)butanoic acid Seleno-DL-Methionine >=99% (TLC) DL-Selenomethionine C05335 2-amino-4-(methylseleno)-butanoicaci 2-Amino-4-(methylselenyl)butyric acid 1-BUTANOIC ACID 2-AMINO-4-(METHYL SELEN O DL-Selenomethionine> DL-Selenomethionine USP/EP/BP DL-Se-Met Selenomethionine (1611955) Selenium methionine seleniummethionine Seleno-DL-methionine Selenomethionine Selenomethionine,DL-Selenomethionine Selenium-selenomethionine 1464-42-2 203211-76-5 2578-28-7 Methionine [Met, M] Amino Acids I - Z Modified Amino Acids