ChemicalBook >> CAS DataBase List >>Manidipine

Manidipine

Manidipine structure

CAS No.: 89226-50-6

Chemical Name:: Manidipine

Synonyms: Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine (Manyper);Manidipine Impurity1254;Manidipine (10mM in DMSO)

CBNumber:: CB4506757

Molecular Formula:: C35H38N4O6

Molecular Weight:: 610.7

MDL Number:: MFCD00871291

MOL File:: 89226-50-6.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

Request For Quotation

Manidipine Properties

Melting point	125-128°C
Boiling point	722.0±60.0 °C(Predicted)
Density	1.232±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO > 10 mM
form	Powder
pka	6.12±0.10(Predicted)
LogP	4.135
FDA UNII	6O4754US88

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

Manidipine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23614	Manidipine ≥98%	89226-50-6	10mg	$110	2024-03-01	Buy
Cayman Chemical	23614	Manidipine ≥98%	89226-50-6	25mg	$206	2024-03-01	Buy
Cayman Chemical	23614	Manidipine ≥98%	89226-50-6	50mg	$352	2024-03-01	Buy
TRC	M164000	Manidipine	89226-50-6	1g	$725	2021-12-16	Buy
Medical Isotopes, Inc.	11462	Manidipine	89226-50-6	100mg	$425	2021-12-16	Buy

Product number	Packaging	Price	Buy
23614	10mg	$110	Buy
23614	25mg	$206	Buy
23614	50mg	$352	Buy
M164000	1g	$725	Buy
11462	100mg	$425	Buy

Manidipine Chemical Properties,Uses,Production

Description

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α_1Cα₂/δβ_1a) and human T-type (α_1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC₅₀ = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A₇r₅ rat vascular smooth muscle cells (ED₅₀ = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC₅₀s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemical Properties

Light Yellow Crystalline Solid

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Definition

ChEBI: Manidipine is a diarylmethane.

Manidipine synthesis

Synthesis of Manidipine from 1-BENZHYDRYLPIPERAZINE

Manidipine Preparation Products And Raw materials

Raw materials

Manidipine Acetyl ketene Methyl 3-aminocrotonate Manidipine hydrochloride 1-(2-Hydroxyethyl)piperazine

Diisopropyl ether Magnesium sulfate 2-(4-Benzhydrylpiperazino)ethyl acetoacetate 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 2-(4-benzhydrylpiperazin-1-yl)ethanol

Methyl 3-nitrobenzylideneacetoacetate 3-Nitrobenzaldehyde 1-BENZHYDRYLPIPERAZINE

1of3

Preparation Products

Manidipine Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Shandong Zhishang New Material Co., Ltd.	+8617653113209	sales002@sdzschem.com	China	3049	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58
InvivoChem	58
Shandong Zhishang New Material Co., Ltd.	58

View Lastest Price from Manidipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Manidipine 89226-50-6	US $38.00-88.00 / mg		100%	10g	TargetMol Chemicals Inc.
2021-07-13	Manidipine 89226-50-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Manidipine 89226-50-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Manidipine
89226-50-6
US $38.00-88.00 / mg
100%
TargetMol Chemicals Inc.

Manidipine
89226-50-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Manidipine
89226-50-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Manidipine Spectrum

Manidipine(89226-50-6)¹HNMR

89226-50-6(Manidipine)Related Search:

Dimethyl sulfide N,N-Dimethylformamide Manidipine hydrochloride Nifedipine Dichlorodiphenylsilane

Nimodipine 1,5-Diphenylcarbazide 1,3-Diphenyl-2-thiourea Amlodipine 3,4'-DIAMINODIPHENYLMETHANE

Dimethyl fumarate Dimethyl ether Chlorodiphenylphosphine Dimethyl sulfoxide Dimethyl phthalate

Diphenyldimethoxysilane ETHANE Methyl

1of4

2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester 89226-75-5 (Di-hydrochloride) 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Manidipine (Manyper) 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI) Franidipine Manidipine 6300 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester Manidipine 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Manidipine(CV-4093) MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE Manidipine（base） Artedil Iperten 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester Manidipine (10mM in DMSO) Manidipine Impurity1254 Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels 89226-50-6 120096-68-4 Inhibitors Artedil, Iperten Dihydropyridine Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals