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GLP-1 receptor agonist 1

GLP-1 receptor agonist 1 Structure
GLP-1 receptor agonist 1 structure
CAS No.
2212020-52-3
Chemical Name:
GLP-1 receptor agonist 1
Synonyms
LY3502970;OWL 833;Orforglipron;Orforglipron（LY3502970）;LY3502970 (Orforglipron);Orforglipron, 10 mM in DMSO;Research Grade Orforglipron;GLP-1 receptor agonist 1 USP/EP/BP;LY3502970|||GLP-1 receptor agonist 1;1,2,4-Oxadiazol-5(2H)-one,3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazChemicalbookol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H
CBNumber:
CB45419742
Molecular Formula:
C48H48F2N10O5
Molecular Weight:
882.97
MDL Number:
MOL File:
2212020-52-3.mol
Last updated:2025-04-17 18:22:24
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GLP-1 receptor agonist 1 Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (141.57 mM)
form Solid
pka 7.33±0.20(Predicted)
color Off-white to light yellow
InChIKey USUWIEBBBWHKNI-BBGRWQLENA-N
FDA UNII 7ZW40D021M

GLP-1 receptor agonist 1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0043632 GLP-1receptoragonist1 99.42% 2212020-52-3 5mg $1100 2021-12-16 Buy
ChemScene CS-0043632 GLP-1receptoragonist1 99.42% 2212020-52-3 10mg $1800 2021-12-16 Buy
ChemScene CS-0043632 GLP-1receptoragonist1 99.42% 2212020-52-3 25mg $3900 2021-12-16 Buy
ChemScene CS-0043632 GLP-1receptoragonist1 99.42% 2212020-52-3 50mg $6500 2021-12-16 Buy
ChemScene CS-0043632 GLP-1receptoragonist1 99.42% 2212020-52-3 100mg $9950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0043632 5mg $1100 Buy
CS-0043632 10mg $1800 Buy
CS-0043632 25mg $3900 Buy
CS-0043632 50mg $6500 Buy
CS-0043632 100mg $9950 Buy

GLP-1 receptor agonist 1 Chemical Properties,Uses,Production

Description

Orforglipron (LY3502970) (GLP-1 receptor agonist 1) is  GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.

Uses

Glucagon-like peptide-1 (GLP-1) agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat type 2 diabetes mellitus and, in some cases, obesity.

in vivo

Orforglipron (0.94-4.8 nM in plasma concentration, i.v., or 0.05-0.1 mg/mL, i.g. for 5 days) suppresses food intake in a dose-dependent manner, promotes insulin secretion and decreases blood glucose in cynomolgus monkey model[1].
Orforglipron (0.05-1.35 mg/kg, i.g.) reaches Cmax 2 hours after administration at all doses, exhibits proportional ratio of increase in plasma drug exposure to dose increase, indicates a dose-dependent absorption in the gastrointestinal tract[1].

Pharmacokinetic Analysis of Orforglipron in cynomolgus monkey [1]

routeDose (mg/kg)Tmax (h)Cmax (ng/mL)AUC0-24h (ng·h/mL)
i.g.0.052.04.7823.7
i.g.0.152.020.7135
i.g.0.452.032.0208
i.g.1.352.01481040
Animal Model:cynomolgus monkey model[1]
Dosage:0.9-4.8 nM; 0.05-0.1 mg/mL
Administration:continuous i.v. administration for 30 minutes until a plasma concentration of 0.9-4.8 nM at steady state;
i.g. for 5 days with dose of 0.05-0.1 mg/mL
Result:Increased insulin secretion and decreased plasma-glucose. Suppressed food intake in a dose-dependent manner.

GLP-1 receptor agonist 1 Preparation Products And Raw materials

Raw materials

Preparation Products

GLP-1 receptor agonist 1 Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Guangyang Jiali Biotechnology Co., Ltd
13407521611 46993711@qq.com China 176 58
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +86-15562555968 info@pharmachemm.com China 334 58
Senova Technology Co. Ltd. 		+86-0755-86703119 +8618503098836 info@senovatech.com China 351 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 19825 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32202 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22854 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Supplier Advantage
Shanghai Guangyang Jiali Biotechnology Co., Ltd
58
Jinan Jianfeng Chemical Co., Ltd 		58
Senova Technology Co. Ltd. 		58
ATK CHEMICAL COMPANY LIMITED 		60
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58

View Lastest Price from GLP-1 receptor agonist 1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Orforglipron pictures 2025-04-28 Orforglipron
2212020-52-3
 US $0.00-0.00 / mg 1mg 99% 5000box Jinan Jianfeng Chemical Co., Ltd
GLP-1 receptor agonist 1 pictures 2025-04-27 GLP-1 receptor agonist 1
2212020-52-3
 US $11.00-1.00 / g 1g 99 10000 S&Y Biochem Co.,Ltd
Orforglipron pictures 2024-08-13 Orforglipron
2212020-52-3
 US $0.00-0.00 / g 1g 98% 10kg Senova Technology Co. Ltd.
  • Orforglipron pictures
  • Orforglipron
    2212020-52-3
  • US $0.00-0.00 / mg
  • 99%
  • Jinan Jianfeng Chemical Co., Ltd
  • Orforglipron pictures
  • Orforglipron
    2212020-52-3
  • US $0.00-0.00 / g
  • 98%
  • Senova Technology Co. Ltd.

2212020-52-3(GLP-1 receptor agonist 1)Related Search:

Ly3502970
1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy... GLP-1 receptor agonist 1 USP/EP/BP LY3502970 Orforglipron Orforglipron（LY3502970） LY3502970 (Orforglipron) 3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one OWL 833 LY3502970|||GLP-1 receptor agonist 1 3-((1S,2S)-1-(5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcyclopropyl]- Orforglipron, 10 mM in DMSO Research Grade Orforglipron 1,2,4-Oxadiazol-5(2H)-one,3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazChemicalbookol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy 1,2,4-Oxadiazol-5(2H)-one,3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazChemicalbookol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H 2212020-52-3 C48H48F2N10O5 1