LY2794193
- CAS No.
- 2173037-97-1
- Chemical Name:
- LY2794193
- Synonyms
- LY2794193;LY-2794193,LY2794193;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-[(3-methoxybenzoyl)amino]-, (1S,2S,4S,5R,6S)-
- CBNumber:
- CB45419777
- Molecular Formula:
- C16H18N2O6
- Molecular Weight:
- 334.32
- MDL Number:
- MOL File:
- 2173037-97-1.mol
LY2794193 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0077322 | LY2794193 99.88% | 2173037-97-1 | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0077322 | LY2794193 99.88% | 2173037-97-1 | 10mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0077322 | LY2794193 99.88% | 2173037-97-1 | 50mg | $2850 | 2021-12-16 | Buy |
| ChemScene | CS-0077322 | LY2794193 99.88% | 2173037-97-1 | 100mg | $3950 | 2021-12-16 | Buy |
LY2794193 Chemical Properties,Uses,Production
Biological Activity
LY2794193 is a potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM).
in vitro
LY2794193 exhihits inhibition of spontaneous Ca 2+ oscillations in cultured rat cortical neurons with an EC 50 of 43.6 nM.
In the rat cortical neuron Ca 2+ oscillation assay, LY2794193 exhibits a biphasic inhibition of spontaneous Ca 2+ transients (high affinity EC 50 =0.44 nM; 48% of the total agonist response; low affinity EC 50 =43.6 nM; 52% of the total agonist response) with combined maximal agonist efficacy (E max ) of 66%. < /p>
in vivo
LY2794193 (1-30 mg/kg, sc), given 30 min prior to PCP (5 mg/kg, sc) leads a dose-related reduction in ambulations.
LY2794193 (1 mg/ kg; iv) exhibits moderate clearance (18.3 mL/min per kg) and volume of distribution (1.17 L/kg) with a calculated plasma half-life (T 1/2 ) of 3.1 h in Male Sprague-Dawley rats.
LY2794193 (3 mg/kg; sc) leads to the rapid appearance in the plasma (AUC=9.9 μM; C max =6.78 μM; T max =0.44 h) and a calculated bioavailability of 121% in male Sprague-Dawley rats.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 1, 3, 10, or 30 mg/kg < /td> |
| Administration: | Administrated sc; given 30 min prior to PCP (5 mg/kg, sc) |
| Result: | A dose-related reduction in ambulations was observed, with the 10 and 30 mg/kg dose groups found to be statistically significant. | < /tr>
target
| mGluR3 0.47 nM (EC 50 ) | mGluR3 0.927 nM (Ki) | mGluR2 47.5 (EC 50 ) | mGluR2 412 (Ki) |
LY2794193 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2794193 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 964 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |