6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- CAS No.
- 2068065-16-5
- Chemical Name:
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- Synonyms
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
- CBNumber:
- CB45441866
- Molecular Formula:
- C8H4BrN3O
- Molecular Weight:
- 238.04
- MDL Number:
- MFCD34182974
- MOL File:
- 2068065-16-5.mol
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Uses,Production
Uses
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancers
Synthesis
At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 | yezhaobao@yfpharm.com | China | 27 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20290 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 302 | 58 |
Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | sales@ryanchem.com | China | 137 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 | sales@mkmeditech.com | China | 1134 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
View Lastest Price from 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-26 | 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
|
US $0.00-0.00 / kg | 1kg | 98% | 500Kilogram/Month | Xiamen Yunfan Biotech Co.,Ltd. | ||
2024-04-09 | 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2022-10-09 | 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
- US $0.00-0.00 / kg
- 98%
- Xiamen Yunfan Biotech Co.,Ltd.
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.