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BIIB068

BIIB068 Structure
BIIB068 structure
CAS No.
1798787-27-5
Chemical Name:
BIIB068
Synonyms
BIIB068;BIIB-068;BIIB068, 10 mM in DMSO;3-Isopropoxy-N-(2-methyl-4-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzyl)azetidine-1-carboxamide;N-[(2-methyl-4-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}phenyl)methyl]-3-(propan-2-yloxy)azetidine-1-carboxamide;1-Azetidinecarboxamide, 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]-;ADME,inhibit,FcγR,Autoimmune,Bruton tyrosine kinase,TNFα,BIIB 068,ROS,Inhibitor,reversible,Btk,anti-IgD,phosphorylation,BIIB068,anti-IgM,BIIB-068
CBNumber:
CB45853001
Molecular Formula:
C23H29N7O2
Molecular Weight:
435.52
MDL Number:
MOL File:
1798787-27-5.mol
Last updated:2025-04-18 09:52:20
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BIIB068 Properties

Density 1.30±0.1 g/cm3(Predicted)
solubility DMSO:30.63(Max Conc. mg/mL);70.33(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);68.88(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);22.96(Max Conc. mM)
form A crystalline solid
pka 13.40±0.40(Predicted)
color Off-white to yellow
FDA UNII M6RN4LQ25S

BIIB068 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0133440 BIIB068 99.20% 1798787-27-5 5mg $180 2021-12-16 Buy
ChemScene CS-0133440 BIIB068 99.20% 1798787-27-5 10mg $300 2021-12-16 Buy
ChemScene CS-0133440 BIIB068 99.20% 1798787-27-5 25mg $550 2021-12-16 Buy
ChemScene CS-0133440 BIIB068 99.20% 1798787-27-5 50mg $950 2021-12-16 Buy
ChemScene CS-0133440 BIIB068 99.20% 1798787-27-5 100mg $1650 2021-12-16 Buy
Product number Packaging Price Buy
CS-0133440 5mg $180 Buy
CS-0133440 10mg $300 Buy
CS-0133440 25mg $550 Buy
CS-0133440 50mg $950 Buy
CS-0133440 100mg $1650 Buy

BIIB068 Chemical Properties,Uses,Production

Uses

BIIB068 is a potent, selective, reversible and orally active BTK inhibitor with an IC50 of 1 nM and a Kd of 0.3 nM. BIIB068 shows more >400-fold selective for BTK than other kinases. BIIB068 has the potential for autoimmune diseases research[1].

in vivo

BIIB068 (compound 1) is stable in the plasma of mouse, rat, beagle dog, and cynomolgus monkey (>95% parent compound remaining after 6 hours of incubation)[1].
BIIB068 (compound 1) exhibits good drug-like properties (LLE = 5) which results in low in vivo clearance (CL %Qh = 6) and moderate oral bioavailability (%F = 48) when dosed in rats. BIIB068 (5 mg/kg; po) treatment shows the T1/2 of 1.2 hours, 2.1 hours and 0.9 hour for rats, dog and cynomolgus monkey, respectively. BIIB068 shows acceptable ADME (absorption, distribution, metabolism, and excretion) properties[1].

References

[1] Bin Ma, Tonika Bohnert, et al. Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J Med Chem. 2020 Jul 22. DOI:10.1021/acs.jmedchem.0c00702

BIIB068 Preparation Products And Raw materials

Raw materials

Preparation Products

BIIB068 Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 310 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4601 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
AgileBioChem Co., Ltd. 18055517827 sales@agilebiochem.com China 999 50
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9329 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
BOC Sciences 65
Shanghai XingMo Biotechnology Co., Ltd. 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
AgileBioChem Co., Ltd. 50
Shanghai Chaolan Chemical Technology Center 58

View Lastest Price from BIIB068 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BIIB068 pictures 2024-11-19 BIIB068
1798787-27-5
 US $66.00-272.00 / mg 98.05% 10g TargetMol Chemicals Inc.
  • BIIB068 pictures
  • BIIB068
    1798787-27-5
  • US $66.00-272.00 / mg
  • 98.05%
  • TargetMol Chemicals Inc.

BIIB068 Spectrum

BIIB068(1798787-27-5)1HNMR
BIIB068 BIIB-068 1-Azetidinecarboxamide, 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]- ADME,inhibit,FcγR,Autoimmune,Bruton tyrosine kinase,TNFα,BIIB 068,ROS,Inhibitor,reversible,Btk,anti-IgD,phosphorylation,BIIB068,anti-IgM,BIIB-068 N-[(2-methyl-4-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}phenyl)methyl]-3-(propan-2-yloxy)azetidine-1-carboxamide 3-Isopropoxy-N-(2-methyl-4-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzyl)azetidine-1-carboxamide BIIB068, 10 mM in DMSO 1798787-27-5