Silver sulfadiazine | 22199-08-2

Silver sulfadiazine Properties

Melting point	285 °C (dec.)(lit.)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
form	powder
color	White to Off-White
Merck	14,8903
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	UEJSSZHHYBHCEL-UHFFFAOYSA-N
CAS DataBase Reference	22199-08-2(CAS DataBase Reference)
FDA UNII	W46JY43EJR
NCI Drug Dictionary	Silvadene
ATC code	D06BA01,D06BA51

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

2

RTECS

WP1950000

HazardClass

IRRITANT

HS Code

2935904000

NFPA 704

	0
2		0

Silver sulfadiazine price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	481181	Silver(I) sulfadiazine 98%	22199-08-2	5g	$65.1	2024-03-01	Buy
Sigma-Aldrich	PHR2654	Silver Sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material	22199-08-2	500MG	$241	2024-03-01	Buy
Sigma-Aldrich	1612608	Silver sulfadiazine United States Pharmacopeia (USP) Reference Standard	22199-08-2	200mg	$572	2024-03-01	Buy
TCI Chemical	S0595	Silver Sulfadiazine >98.0%(HPLC)(T)	22199-08-2	5g	$58	2024-03-01	Buy
TCI Chemical	S0595	Silver Sulfadiazine >98.0%(HPLC)(T)	22199-08-2	25g	$187	2024-03-01	Buy

Product number	Packaging	Price	Buy
481181	5g	$65.1	Buy
PHR2654	500MG	$241	Buy
1612608	200mg	$572	Buy
S0595	5g	$58	Buy
S0595	25g	$187	Buy

Silver sulfadiazine Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Uses

Coordination compound. Antibacterial

Uses

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

Definition

ChEBI: Silver(1+) sulfadiazinate is a silver salt, a sulfonamidate and a member of pyrimidines. It has a role as an antimicrobial agent and an antibacterial drug. It contains a sulfadiazinate.

Indications

Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell wall. It is used primarily as an adjunct in the prevention and treatment of wound sepsis in patients with second- and third-degree burns and for wound care of chronic ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those sensitive to silver nitrate but resistant to sulfadiazine, have shown good response to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance, and does not cause systemic acidosis. Some patients note a stinging sensation on application, and because this compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur.

Pharmaceutical Applications

Silver sulfadiazine is indicated for the prophylaxis and treatment of infections in burn wounds. Silver sulfadiazine is highly insoluble in water, and as a result, it does not cause hypochloraemia in burns in contrast to silver nitrate.
The active ingredient silver sulfadiazine is a sulfur-derived topical antibacterial used primarily on secondand third-degree burns. It is known to be active against many Gram-negative and Gram-positive bacteria as well as against yeast. The cream is kept applied to the burned skin at all times for the duration of the healing period or until a graft is applied. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Caution has to be given to large-area application as sulfadiazine levels in the plasma may well reach therapeutic levels that can cause side effects.

Pharmaceutical Applications

Silver sulfadiazine is extremely insoluble. In addition to the usual activity of sulfonamides it exhibits activity – almost certainly attributable to the silver component – against Ps. aeruginosa and some fungi.
It is variably absorbed after topical application depending on the integrity of the skin. Toxic concentrations may be achieved in patients with extensive burns. It is used topically, mainly for burns, pressure sores and leg ulcers. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have been developed to reduce bacterial colonization. Other suggested uses include the prevention of infection in skin graft donor sites and cord care in newborn infants.

Clinical Use

The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.

Veterinary Drugs and Treatments

Silver sulfadiazine cream is a broad spectrum agent which covers bacteria (gram positive and negative) and fungal agents. It has been used extensively in people suffering from skin burns. It is nontoxic to the skin, conjunctiva and cornea and has been used in the last several years for cases of fungal keratitis. Particularly good results have been noted in cases of superficial keratitis prior to development of advanced disease. Clinical response is better when used early in the course of the disease. Treatment with silver sulfadiazine is considered non-conventional in people. It is gaining in popularity in the treatment of equine fungal keratitis by veterinary ophthalmologists. For medico-legal reasons, in very expensive horses in which litigation may be an issue, treatment with more conventional therapy (natamycin) may be indicated first, or consideration can be given to signed consent regarding treatment with silver sulfadiazine. The initial response to this drug has been promising, however.

Veterinary Drugs and Treatments

Topical silver sulfadiazine (SSD) is used topically for prophylaxis and treatment of 2nd and 3rd degree burns. It is also useful in treating localized pyodermas caused by Pseudomonas spp.
SSD has extensive antimicrobial activity and is bactericidal for yeasts and many gram-negative and gram-positive bacteria. SSD acts via disrupting microbial cell membranes and cell walls; this differs from the antibacterial actions of silver nitrate or sodium sulfadiazine.

Silver sulfadiazine Preparation Products And Raw materials

Raw materials

Preparation Products

Silver sulfadiazine Suppliers

Global( 385)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5975	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20285	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	295	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	299	55

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hangzhou Hyper Chemicals Limited	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Shanghai Bojing Chemical Co.,Ltd.	55

View Lastest Price from Silver sulfadiazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-18	Silver sulfadiazine 22199-08-2	US $40.00 / kg	1kg	99%	5000kg/Week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-12-13	Silver sulfadiazine 22199-08-2	US $0.00 / Kg/Drum	1KG	98%-102%	1000KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-14	Silver sulfadiazine 22199-08-2	US $720.00 / KG	1KG	98%	1-20mt	Baoji Guokang Bio-Technology Co., Ltd.

Silver sulfadiazine
22199-08-2
US $40.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Silver sulfadiazine
22199-08-2
US $0.00 / Kg/Drum
98%-102%
WUHAN FORTUNA CHEMICAL CO., LTD

Silver sulfadiazine
22199-08-2
US $720.00 / KG
98%
Baoji Guokang Bio-Technology Co., Ltd.

22199-08-2(Silver sulfadiazine)Related Search:

Glycine Sulfanilic acid 3-Aminophenol Sodium sulfadiazine Tris(hydroxymethyl)aminomethane

6-Aminocaproic acid 4-Aminobenzoic acid p-Toluenesulfonamide Sulfuryl chloride p-Anisidine

Sulfanilamide Silver Sulfadiazine Sulfamerazine Mercury

Aniline ALTRENOGEST Sulfamethoxypyridazine

1of4

silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide SILVER SULFADIAZINE SULPHADIAZINE-AG 4-amino-n-(2-pyrimidinyl)benzenesulfonamidesilversalt 4-amino-n-2-pyrimidinylbenzenesulfonamide monosilver salt (4-amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver [4-Amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]silver 4-Amino-N-2-pyrimidinylbenzenesulfonamide Silver Complex Dermazin Flammazine Silver, 4-amino-N-(2-pyrimidinyl-.kappa.N1)benzenesulfonamidato-.kappa.O- SILVERSULFADIAZINE,MICRONIZED SILVERSULFADIAZINE,MICRONIZED,USP sulfadiazine silver，SD-Ag Sulfadiazine,Siliver salt 4-Amino-N-2-pyrimidinylbenzenesulfonamide monosilver(1+) salt Sulfadiazine sailver salt Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex Nsc625324 Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-nn,o1)- Sulfadiazine silversilvadene Silver Sulfdiazine SD-Ag Silver Sulfadiazine (200 mg) 3-(4-aMinophenyl)-3-oxo-1H,4H-2$l^{3},3$l^{6},4,5,9000000$l^{5},1-pyriMido[2,1-d]1$l^{3}-oxa-2$l^{6}-thia-3,5$l^{5}-diaza-6-argentacyclohexan-1-yliuM-4-id-9-yl SILVER(I) SULFADIAZINE 98% Silver suifadiazine Silver,[4-aMino-N-(2-pyriMidinyl-kN1)benzenesulfonaMidato-kO]- 4-amino-n-2-pyrimidinyl-benzenesulfonamidmonosilver(1+)salt dermazine flamazine geben n(sup1)-2-pyrimidinyl-sulfanilamidmonosilver(1+)salt sulfadiazinesilversalt (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide Sulfadiazine silver Sulfadiazine Silver Salt SD-Ag silver(1+) sulfadiazinate silver 4-amino-N-(2-pyrimidinyl)benzenesulfonamide silver sulfadiazine powder Silver(1+) [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide SilverSulfadiazine> Sulfadiazine Silver RS Silver sulfadiazine USP/EP/BP Silver(I) ((4-Aminophenyl)sulfonyl)(pyrimidin-2-yl)amide Silver Sulfadiazine ExiPlus, Multi-Compendial, 98% Silver Sulfadiazine (1612608) SILVER(I) SULFADIAZINE SILVER SULPHADIAZINE SULFADIAZINE SILVER silvadene SILVER SULPHADIAIZINE Silver Sulfadiazine, ≥ 98.0% SuIfadiazine Silver Silvadene|||Dermazin|||Flamazine 22199-08-2 722199-08-2 1715998-31-4 C10H9AgN4O2S