2-Chloro-4,6-dimethoxy-1,3,5-triazine
- CAS No.
- 3140-73-6
- Chemical Name:
- 2-Chloro-4,6-dimethoxy-1,3,5-triazine
- Synonyms
- CDMT;AKOS 89995;CDMT 2-Chloro-4,6-diMethoxy-1,3,5-triazine;Chlorodimethoxytriazine;NSC 46520;6-diMethoxy-1;5-triazine (CDMT);2-Chloro-4,6-dimetho;2-Chloro-4,6-dimethoxy-1;2-CHLORO-4,6-DIMETHOXY-TRIAZINE
- CBNumber:
- CB4775597
- Molecular Formula:
- C5H6ClN3O2
- Molecular Weight:
- 175.57
- MDL Number:
- MFCD00075607
- MOL File:
- 3140-73-6.mol
- MSDS File:
- SDS
Melting point | 71-74 °C (lit.) |
---|---|
Boiling point | 99-100 °C (1 mmHg) |
Density | 1.7917 (rough estimate) |
vapor pressure | 5.8Pa at 25℃ |
refractive index | 1.5870 (estimate) |
Flash point | 99-100°C/1mm |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform, Methanol |
form | Crystalline Powder |
pka | 0.33±0.10(Predicted) |
color | White to almost white |
Water Solubility | insoluble |
BRN | 148988 |
InChIKey | GPIQOFWTZXXOOV-UHFFFAOYSA-N |
LogP | 2.105 at 25℃ |
CAS DataBase Reference | 3140-73-6(CAS DataBase Reference) |
FDA UNII | 6KB2H8FE5Q |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37-36 | |||||||||
RIDADR | UN3077 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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2-Chloro-4,6-dimethoxy-1,3,5-triazine price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 375217 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine 97% | 3140-73-6 | 5g | $63.7 | 2024-03-01 | Buy |
TCI Chemical | C1676 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine >97.0%(HPLC)(T) | 3140-73-6 | 5g | $20 | 2024-03-01 | Buy |
TCI Chemical | C1676 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine >97.0%(HPLC)(T) | 3140-73-6 | 25g | $39 | 2024-03-01 | Buy |
Alfa Aesar | B24474 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98% | 3140-73-6 | 5g | $43.65 | 2024-03-01 | Buy |
Alfa Aesar | B24474 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98% | 3140-73-6 | 25g | $126 | 2024-03-01 | Buy |
2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties,Uses,Production
Chemical Properties
white to almost white crystalline powder
Uses
2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:
- The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
- The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
- The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
- The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.
Uses
2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.
General Description
2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.
Synthesis
A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.
2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3958 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5822 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18777 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
View Lastest Price from 2-Chloro-4,6-dimethoxy-1,3,5-triazine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-22 | CDMT 2-Chloro-4,6-dimethoxy-1,3,5-triazine
3140-73-6
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | ||
2024-11-22 | 2-Chloro-4,6-dimethoxy-1,3,5-triazine/CDMT
3140-73-6
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 1000 KG | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-10-15 | 2-chloro-4,6-dimethoxy-1,3,5-triazine
3140-73-6
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. |
- CDMT 2-Chloro-4,6-dimethoxy-1,3,5-triazine
3140-73-6
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
- 2-Chloro-4,6-dimethoxy-1,3,5-triazine/CDMT
3140-73-6
- US $0.00-0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 2-chloro-4,6-dimethoxy-1,3,5-triazine
3140-73-6
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
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